Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium

Phong A Tran1, Love Sarin2, Robert H Hurt2, Thomas J Webster2,31Physics Department,2Division of Engineering,3Department of Orthopedic Surgery, Brown University, Providence, RI, USAAbstract: In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti)...

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Autores principales:	Phong A Tran, Love Sarin, Robert H Hurt, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f70a1307c4b3496387bdead2f4c98a2e
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spelling	oai:doaj.org-article:f70a1307c4b3496387bdead2f4c98a2e2021-12-02T01:35:40ZDifferential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium1176-91141178-2013https://doaj.org/article/f70a1307c4b3496387bdead2f4c98a2e2010-05-01T00:00:00Zhttp://www.dovepress.com/differential-effects-of-nanoselenium-doping-on-healthy-and-cancerous-o-a4396https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Phong A Tran1, Love Sarin2, Robert H Hurt2, Thomas J Webster2,31Physics Department,2Division of Engineering,3Department of Orthopedic Surgery, Brown University, Providence, RI, USAAbstract: In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti) surfaces, a common orthopedic implant material. Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities. For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment. This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.Keywords: selenium, coating, nanotechnology, biomaterials, orthopedics, bone cancer Phong A TranLove SarinRobert H Hurtet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 351-358 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Phong A Tran Love Sarin Robert H Hurt et al Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
description	Phong A Tran1, Love Sarin2, Robert H Hurt2, Thomas J Webster2,31Physics Department,2Division of Engineering,3Department of Orthopedic Surgery, Brown University, Providence, RI, USAAbstract: In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti) surfaces, a common orthopedic implant material. Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities. For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment. This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.Keywords: selenium, coating, nanotechnology, biomaterials, orthopedics, bone cancer
format	article
author	Phong A Tran Love Sarin Robert H Hurt et al
author_facet	Phong A Tran Love Sarin Robert H Hurt et al
author_sort	Phong A Tran
title	Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
title_short	Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
title_full	Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
title_fullStr	Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
title_full_unstemmed	Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
title_sort	differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/f70a1307c4b3496387bdead2f4c98a2e
work_keys_str_mv	AT phongatran differentialeffectsofnanoseleniumdopingonhealthyandcancerousosteoblastsincocultureontitanium AT lovesarin differentialeffectsofnanoseleniumdopingonhealthyandcancerousosteoblastsincocultureontitanium AT roberthhurt differentialeffectsofnanoseleniumdopingonhealthyandcancerousosteoblastsincocultureontitanium AT etal differentialeffectsofnanoseleniumdopingonhealthyandcancerousosteoblastsincocultureontitanium
_version_	1718402992859774976

Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium

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