GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients

Abstract Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their correspond...

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Autores principales:	Rania H. Mahmoud, Enas Mamdouh Hefzy, Olfat G. Shaker, Tarek I. Ahmed, Noha K. Abdelghaffar, Essam A. Hassan, Amal A. Ibrahim, Doaa Y. Ali, Mohamed M. Mohamed, Omayma O. Abdelaleem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f70bc44957ef46e89717d93b6c4b3c51
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spelling	oai:doaj.org-article:f70bc44957ef46e89717d93b6c4b3c512021-12-02T19:16:14ZGAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients10.1038/s41598-021-99345-22045-2322https://doaj.org/article/f70bc44957ef46e89717d93b6c4b3c512021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99345-2https://doaj.org/toc/2045-2322Abstract Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p < 0.001), while the dominant CC was a protective factor (p = 0.004). Regarding miR-137 rs1625579, the mutant genotype TT was reported as a risk factor for CHBV (p < 0.001) and the normal GG genotype was a protective factor, p < 0.001. The serum GAS5 was significantly higher in the mutant TT genotype of GAS5 SNP as compared to the other genotypes (p = 0.007). Concerning miR-137 rs1625579, the mutant TT genotype was significantly associated with a lower serum expression level of miR-137 (p = 0.018). We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets.Rania H. MahmoudEnas Mamdouh HefzyOlfat G. ShakerTarek I. AhmedNoha K. AbdelghaffarEssam A. HassanAmal A. IbrahimDoaa Y. AliMohamed M. MohamedOmayma O. AbdelaleemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rania H. Mahmoud Enas Mamdouh Hefzy Olfat G. Shaker Tarek I. Ahmed Noha K. Abdelghaffar Essam A. Hassan Amal A. Ibrahim Doaa Y. Ali Mohamed M. Mohamed Omayma O. Abdelaleem GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
description	Abstract Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p < 0.001), while the dominant CC was a protective factor (p = 0.004). Regarding miR-137 rs1625579, the mutant genotype TT was reported as a risk factor for CHBV (p < 0.001) and the normal GG genotype was a protective factor, p < 0.001. The serum GAS5 was significantly higher in the mutant TT genotype of GAS5 SNP as compared to the other genotypes (p = 0.007). Concerning miR-137 rs1625579, the mutant TT genotype was significantly associated with a lower serum expression level of miR-137 (p = 0.018). We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets.
format	article
author	Rania H. Mahmoud Enas Mamdouh Hefzy Olfat G. Shaker Tarek I. Ahmed Noha K. Abdelghaffar Essam A. Hassan Amal A. Ibrahim Doaa Y. Ali Mohamed M. Mohamed Omayma O. Abdelaleem
author_facet	Rania H. Mahmoud Enas Mamdouh Hefzy Olfat G. Shaker Tarek I. Ahmed Noha K. Abdelghaffar Essam A. Hassan Amal A. Ibrahim Doaa Y. Ali Mohamed M. Mohamed Omayma O. Abdelaleem
author_sort	Rania H. Mahmoud
title	GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
title_short	GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
title_full	GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
title_fullStr	GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
title_full_unstemmed	GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients
title_sort	gas5 rs2067079 and mir-137 rs1625579 functional snps and risk of chronic hepatitis b virus infection among egyptian patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f70bc44957ef46e89717d93b6c4b3c51
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GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients

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