Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure

Introduction: Both aluminium and ethanol are pro-oxidants and neurotoxic. Moderately intake of alcohol may favor the body in coronary heart disease and diabetes mellitus etc. Being cheaper aluminium and increasing consumption of alcohol in India mixed with each other and may induce neurotoxicity. Th...

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Autores principales:	Buddhadeb Ghosh, Ravi Kant Sharma, Suman Yadav
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	aluminium cerebellum ethanol neurodegeneration neurotoxicity purkinje cells Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/f70ccb73f8694470bcea5f1655c92f8a
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spelling	oai:doaj.org-article:f70ccb73f8694470bcea5f1655c92f8a2021-11-19T12:15:52ZAluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure0975-740610.4103/jpbs.jpbs_377_21https://doaj.org/article/f70ccb73f8694470bcea5f1655c92f8a2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1228;epage=1233;aulast=Ghoshhttps://doaj.org/toc/0975-7406Introduction: Both aluminium and ethanol are pro-oxidants and neurotoxic. Moderately intake of alcohol may favor the body in coronary heart disease and diabetes mellitus etc. Being cheaper aluminium and increasing consumption of alcohol in India mixed with each other and may induce neurotoxicity. The present study was planned to identify the level of aluminium induced neurodegeneration in presence of ethanol coexposure in the cerebellum. Materials and Methods: An experimental study was carried out at Dr. RP Government Medical College, Kangra, and Government Medical College, Amritsar, India after due approval from the Institute Animal Ethics Committee. Thirty-two Wistar rats were divided into one vehicle control and three experimental groups. Group I received the normal saline water as the vehicle control group. Group II received aluminium chloride 4.2 mg/kg body weight as the experimental group. Group III received ethanol 1 g/kg body weight as the experimental group. Group IV received both aluminium chloride 4.2 mg/kg body weight and ethanol 1 g/kg body weight as the experimental group. After 3 months of treatment, cerebellum was processed for histopathological observation under the microscope. Results: Experimental group treated with aluminium and ethanol separately showed reduction in the number of Purkinje cells, without a prominent nucleolus and well-defined nuclear membrane. Eosinophilic swelling adjacent to Purkinje cell bodies observed. The effects of combined administration of aluminium ethanol treated groups showed with acute neurodegeneration of Purkinje cell layer and granular layer. Pyknosis and neurofibrillary tangle seen in Purkinje cells. Conclusions: It has been suggested that the ethanol-induced the effects of aluminium on the cerebellum and plays a significant role in neurotoxicity.Buddhadeb GhoshRavi Kant SharmaSuman YadavWolters Kluwer Medknow Publicationsarticlealuminiumcerebellumethanolneurodegenerationneurotoxicitypurkinje cellsPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1228-1233 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aluminium cerebellum ethanol neurodegeneration neurotoxicity purkinje cells Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	aluminium cerebellum ethanol neurodegeneration neurotoxicity purkinje cells Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Buddhadeb Ghosh Ravi Kant Sharma Suman Yadav Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
description	Introduction: Both aluminium and ethanol are pro-oxidants and neurotoxic. Moderately intake of alcohol may favor the body in coronary heart disease and diabetes mellitus etc. Being cheaper aluminium and increasing consumption of alcohol in India mixed with each other and may induce neurotoxicity. The present study was planned to identify the level of aluminium induced neurodegeneration in presence of ethanol coexposure in the cerebellum. Materials and Methods: An experimental study was carried out at Dr. RP Government Medical College, Kangra, and Government Medical College, Amritsar, India after due approval from the Institute Animal Ethics Committee. Thirty-two Wistar rats were divided into one vehicle control and three experimental groups. Group I received the normal saline water as the vehicle control group. Group II received aluminium chloride 4.2 mg/kg body weight as the experimental group. Group III received ethanol 1 g/kg body weight as the experimental group. Group IV received both aluminium chloride 4.2 mg/kg body weight and ethanol 1 g/kg body weight as the experimental group. After 3 months of treatment, cerebellum was processed for histopathological observation under the microscope. Results: Experimental group treated with aluminium and ethanol separately showed reduction in the number of Purkinje cells, without a prominent nucleolus and well-defined nuclear membrane. Eosinophilic swelling adjacent to Purkinje cell bodies observed. The effects of combined administration of aluminium ethanol treated groups showed with acute neurodegeneration of Purkinje cell layer and granular layer. Pyknosis and neurofibrillary tangle seen in Purkinje cells. Conclusions: It has been suggested that the ethanol-induced the effects of aluminium on the cerebellum and plays a significant role in neurotoxicity.
format	article
author	Buddhadeb Ghosh Ravi Kant Sharma Suman Yadav
author_facet	Buddhadeb Ghosh Ravi Kant Sharma Suman Yadav
author_sort	Buddhadeb Ghosh
title	Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
title_short	Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
title_full	Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
title_fullStr	Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
title_full_unstemmed	Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
title_sort	aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/f70ccb73f8694470bcea5f1655c92f8a
work_keys_str_mv	AT buddhadebghosh aluminiuminducedneurodegenerationinratcerebelluminthepresenceofethanolcoexposure AT ravikantsharma aluminiuminducedneurodegenerationinratcerebelluminthepresenceofethanolcoexposure AT sumanyadav aluminiuminducedneurodegenerationinratcerebelluminthepresenceofethanolcoexposure
_version_	1718420170291019776

Aluminium induced neurodegeneration in rat cerebellum in the presence of ethanol coexposure

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