miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis,...

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Autores principales:	Yun Ji, Jessica Fioravanti, Wei Zhu, Hongjun Wang, Tuoqi Wu, Jinhui Hu, Neal E. Lacey, Sanjivan Gautam, John B. Le Gall, Xia Yang, James D. Hocker, Thelma M. Escobar, Shan He, Stefania Dell’Orso, Nga V. Hawk, Veena Kapoor, William G. Telford, Luciano Di Croce, Stefan A. Muljo, Yi Zhang, Vittorio Sartorelli, Luca Gattinoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7106871939f484092d79cd389893db3
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spelling	oai:doaj.org-article:f7106871939f484092d79cd389893db32021-12-02T15:35:59ZmiR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate10.1038/s41467-019-09882-82041-1723https://doaj.org/article/f7106871939f484092d79cd389893db32019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09882-8https://doaj.org/toc/2041-1723The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.Yun JiJessica FioravantiWei ZhuHongjun WangTuoqi WuJinhui HuNeal E. LaceySanjivan GautamJohn B. Le GallXia YangJames D. HockerThelma M. EscobarShan HeStefania Dell’OrsoNga V. HawkVeena KapoorWilliam G. TelfordLuciano Di CroceStefan A. MuljoYi ZhangVittorio SartorelliLuca GattinoniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun Ji Jessica Fioravanti Wei Zhu Hongjun Wang Tuoqi Wu Jinhui Hu Neal E. Lacey Sanjivan Gautam John B. Le Gall Xia Yang James D. Hocker Thelma M. Escobar Shan He Stefania Dell’Orso Nga V. Hawk Veena Kapoor William G. Telford Luciano Di Croce Stefan A. Muljo Yi Zhang Vittorio Sartorelli Luca Gattinoni miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
description	The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.
format	article
author	Yun Ji Jessica Fioravanti Wei Zhu Hongjun Wang Tuoqi Wu Jinhui Hu Neal E. Lacey Sanjivan Gautam John B. Le Gall Xia Yang James D. Hocker Thelma M. Escobar Shan He Stefania Dell’Orso Nga V. Hawk Veena Kapoor William G. Telford Luciano Di Croce Stefan A. Muljo Yi Zhang Vittorio Sartorelli Luca Gattinoni
author_facet	Yun Ji Jessica Fioravanti Wei Zhu Hongjun Wang Tuoqi Wu Jinhui Hu Neal E. Lacey Sanjivan Gautam John B. Le Gall Xia Yang James D. Hocker Thelma M. Escobar Shan He Stefania Dell’Orso Nga V. Hawk Veena Kapoor William G. Telford Luciano Di Croce Stefan A. Muljo Yi Zhang Vittorio Sartorelli Luca Gattinoni
author_sort	Yun Ji
title	miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
title_short	miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
title_full	miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
title_fullStr	miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
title_full_unstemmed	miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
title_sort	mir-155 harnesses phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of cd8+ t cell fate
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f7106871939f484092d79cd389893db3
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miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

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