Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death

Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death

Abstract Proximal tubular cells (PTC) are particularly vulnerable to hypoxia-induced apoptosis, a relevant factor for kidney disease. We hypothesized here that PTC death under hypoxia is mediated by cyclo-oxygenase (COX-2)-dependent production of prostaglandin E2 (PGE2), which was confirmed in human...

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Autores principales: Coral García-Pastor, Selma Benito-Martínez, Ricardo J. Bosch, Ana B. Fernández-Martínez, Francisco J. Lucio-Cazaña
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f711417c43074f3f8a7eb7b6f2956e11
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