CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 snRNP by other alternative splicing factors.

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Autores principales:	Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7115a6e9abb4a48ae84dd84cc1e01b0
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spelling	oai:doaj.org-article:f7115a6e9abb4a48ae84dd84cc1e01b02021-12-02T15:38:34ZCryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing10.1038/s41467-017-01241-92041-1723https://doaj.org/article/f7115a6e9abb4a48ae84dd84cc1e01b02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01241-9https://doaj.org/toc/2041-1723U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 snRNP by other alternative splicing factors.Xueni LiShiheng LiuJiansen JiangLingdi ZhangSara EspinosaRyan C. HillKirk C. HansenZ. Hong ZhouRui ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xueni Li Shiheng Liu Jiansen Jiang Lingdi Zhang Sara Espinosa Ryan C. Hill Kirk C. Hansen Z. Hong Zhou Rui Zhao CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
description	U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 snRNP by other alternative splicing factors.
format	article
author	Xueni Li Shiheng Liu Jiansen Jiang Lingdi Zhang Sara Espinosa Ryan C. Hill Kirk C. Hansen Z. Hong Zhou Rui Zhao
author_facet	Xueni Li Shiheng Liu Jiansen Jiang Lingdi Zhang Sara Espinosa Ryan C. Hill Kirk C. Hansen Z. Hong Zhou Rui Zhao
author_sort	Xueni Li
title	CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
title_short	CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
title_full	CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
title_fullStr	CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
title_full_unstemmed	CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
title_sort	cryoem structure of saccharomyces cerevisiae u1 snrnp offers insight into alternative splicing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7115a6e9abb4a48ae84dd84cc1e01b0
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CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

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