CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 snRNP by other alternative splicing factors.

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Detalles Bibliográficos
Autores principales: Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/f7115a6e9abb4a48ae84dd84cc1e01b0
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