Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention

Abstract Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness...

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Autores principales:	Adrian Escriche-Escuder, Manuel Trinidad-Fernández, Bella Pajares, Marcos Iglesias-Campos, Emilio Alba, Antonio I. Cuesta-Vargas, Cristina Roldán-Jiménez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f712c4c916254502b38875915f1cefa2
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spelling	oai:doaj.org-article:f712c4c916254502b38875915f1cefa22021-12-02T16:45:31ZUltrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention10.1038/s41598-021-88375-52045-2322https://doaj.org/article/f712c4c916254502b38875915f1cefa22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88375-5https://doaj.org/toc/2045-2322Abstract Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients.Adrian Escriche-EscuderManuel Trinidad-FernándezBella PajaresMarcos Iglesias-CamposEmilio AlbaAntonio I. Cuesta-VargasCristina Roldán-JiménezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adrian Escriche-Escuder Manuel Trinidad-Fernández Bella Pajares Marcos Iglesias-Campos Emilio Alba Antonio I. Cuesta-Vargas Cristina Roldán-Jiménez Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
description	Abstract Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients.
format	article
author	Adrian Escriche-Escuder Manuel Trinidad-Fernández Bella Pajares Marcos Iglesias-Campos Emilio Alba Antonio I. Cuesta-Vargas Cristina Roldán-Jiménez
author_facet	Adrian Escriche-Escuder Manuel Trinidad-Fernández Bella Pajares Marcos Iglesias-Campos Emilio Alba Antonio I. Cuesta-Vargas Cristina Roldán-Jiménez
author_sort	Adrian Escriche-Escuder
title	Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
title_short	Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
title_full	Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
title_fullStr	Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
title_full_unstemmed	Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
title_sort	ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f712c4c916254502b38875915f1cefa2
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Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention

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