Histone acetyltransferase PfGCN5 regulates stress responsive and artemisinin resistance related genes in Plasmodium falciparum
Abstract Plasmodium falciparum has evolved resistance to almost all front-line drugs including artemisinin, which threatens malaria control and elimination strategies. Oxidative stress and protein damage responses have emerged as key players in the generation of artemisinin resistance. In this study...
Enregistré dans:
Auteurs principaux: | Mukul Rawat, Abhishek Kanyal, Aishwarya Sahasrabudhe, Shruthi Sridhar Vembar, Jose-Juan Lopez-Rubio, Krishanpal Karmodiya |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f714722b9378468596438180022cd502 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase.
par: Junfeng Jiang, et autres
Publié: (2012) -
A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum.
par: Jun Miao, et autres
Publié: (2021) -
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
par: M. Isabel Veiga, et autres
Publié: (2016) -
N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi
par: Chang Su, et autres
Publié: (2016) -
Structural characterization of a Gcn5-related N-acetyltransferase from Staphylococcus aureus.
par: Parul Srivastava, et autres
Publié: (2014)