A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

Nanoparticle-based strategies have been proposed to enhance the benefit of cancer immunotherapy. Here the authors show that a cancer vaccine based on metal organic frameworks-gated mesoporous silica nanoparticles for antigen and immune potentiators delivery boosts the therapeutic efficacy of low-dos...

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Autores principales:	Xia Li, Xiupeng Wang, Atsuo Ito, Noriko M. Tsuji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f71839f40174497792c5136e0d1bd3f5
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spelling	oai:doaj.org-article:f71839f40174497792c5136e0d1bd3f52021-12-02T16:23:44ZA nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity10.1038/s41467-020-17637-z2041-1723https://doaj.org/article/f71839f40174497792c5136e0d1bd3f52020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17637-zhttps://doaj.org/toc/2041-1723Nanoparticle-based strategies have been proposed to enhance the benefit of cancer immunotherapy. Here the authors show that a cancer vaccine based on metal organic frameworks-gated mesoporous silica nanoparticles for antigen and immune potentiators delivery boosts the therapeutic efficacy of low-dose anti-PD1.Xia LiXiupeng WangAtsuo ItoNoriko M. TsujiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Li Xiupeng Wang Atsuo Ito Noriko M. Tsuji A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
description	Nanoparticle-based strategies have been proposed to enhance the benefit of cancer immunotherapy. Here the authors show that a cancer vaccine based on metal organic frameworks-gated mesoporous silica nanoparticles for antigen and immune potentiators delivery boosts the therapeutic efficacy of low-dose anti-PD1.
format	article
author	Xia Li Xiupeng Wang Atsuo Ito Noriko M. Tsuji
author_facet	Xia Li Xiupeng Wang Atsuo Ito Noriko M. Tsuji
author_sort	Xia Li
title	A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
title_short	A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
title_full	A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
title_fullStr	A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
title_full_unstemmed	A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
title_sort	nanoscale metal organic frameworks-based vaccine synergises with pd-1 blockade to potentiate anti-tumour immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f71839f40174497792c5136e0d1bd3f5
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A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

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