HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.

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Autores principales:	Huarong Wang, Han Cai, Xiao Wang, Meiling Zhang, Bingying Liu, Ziqi Chen, Tingting Yang, Junshun Fang, Yanhao Zhang, Wei Liu, Jun Han, Qirui Guo, Hua Zhang, Haibin Wang, Guoliang Xia, Chao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f718ed2ab75b4cfbba4e22d2777a330a
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spelling	oai:doaj.org-article:f718ed2ab75b4cfbba4e22d2777a330a2021-12-02T13:23:54ZHDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge10.1038/s41467-019-13671-82041-1723https://doaj.org/article/f718ed2ab75b4cfbba4e22d2777a330a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13671-8https://doaj.org/toc/2041-1723Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.Huarong WangHan CaiXiao WangMeiling ZhangBingying LiuZiqi ChenTingting YangJunshun FangYanhao ZhangWei LiuJun HanQirui GuoHua ZhangHaibin WangGuoliang XiaChao WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huarong Wang Han Cai Xiao Wang Meiling Zhang Bingying Liu Ziqi Chen Tingting Yang Junshun Fang Yanhao Zhang Wei Liu Jun Han Qirui Guo Hua Zhang Haibin Wang Guoliang Xia Chao Wang HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
description	Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.
format	article
author	Huarong Wang Han Cai Xiao Wang Meiling Zhang Bingying Liu Ziqi Chen Tingting Yang Junshun Fang Yanhao Zhang Wei Liu Jun Han Qirui Guo Hua Zhang Haibin Wang Guoliang Xia Chao Wang
author_facet	Huarong Wang Han Cai Xiao Wang Meiling Zhang Bingying Liu Ziqi Chen Tingting Yang Junshun Fang Yanhao Zhang Wei Liu Jun Han Qirui Guo Hua Zhang Haibin Wang Guoliang Xia Chao Wang
author_sort	Huarong Wang
title	HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
title_short	HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
title_full	HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
title_fullStr	HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
title_full_unstemmed	HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
title_sort	hdac3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the lh surge
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f718ed2ab75b4cfbba4e22d2777a330a
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HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

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