HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
Before ovulation, a surge of luteinizing hormone (LH) triggers the resumption of meiosis in oocytes, which is mediated by EGF-like growth factors. Here, the authors show that HDAC3 inhibits mouse oocyte maturation by negatively regulating the expression of EGF-like factor before the LH surge.
Guardado en:
Autores principales: | Huarong Wang, Han Cai, Xiao Wang, Meiling Zhang, Bingying Liu, Ziqi Chen, Tingting Yang, Junshun Fang, Yanhao Zhang, Wei Liu, Jun Han, Qirui Guo, Hua Zhang, Haibin Wang, Guoliang Xia, Chao Wang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/f718ed2ab75b4cfbba4e22d2777a330a |
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