Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomohito Izumi, Junta Imai, Junpei Yamamoto, Yohei Kawana, Akira Endo, Hiroto Sugawara, Masato Kohata, Yoichiro Asai, Kei Takahashi, Shinjiro Kodama, Keizo Kaneko, Junhong Gao, Kenji Uno, Shojiro Sawada, Vladimir V. Kalinichenko, Yasushi Ishigaki, Tetsuya Yamada, Hideki Katagiri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f719e1036e594ff69a5c540261de719c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f719e1036e594ff69a5c540261de719c
record_format	dspace
spelling	oai:doaj.org-article:f719e1036e594ff69a5c540261de719c2021-12-02T17:32:02ZVagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation10.1038/s41467-018-07747-02041-1723https://doaj.org/article/f719e1036e594ff69a5c540261de719c2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07747-0https://doaj.org/toc/2041-1723The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activation and promotion of overall survival.Tomohito IzumiJunta ImaiJunpei YamamotoYohei KawanaAkira EndoHiroto SugawaraMasato KohataYoichiro AsaiKei TakahashiShinjiro KodamaKeizo KanekoJunhong GaoKenji UnoShojiro SawadaVladimir V. KalinichenkoYasushi IshigakiTetsuya YamadaHideki KatagiriNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomohito Izumi Junta Imai Junpei Yamamoto Yohei Kawana Akira Endo Hiroto Sugawara Masato Kohata Yoichiro Asai Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Vladimir V. Kalinichenko Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
description	The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activation and promotion of overall survival.
format	article
author	Tomohito Izumi Junta Imai Junpei Yamamoto Yohei Kawana Akira Endo Hiroto Sugawara Masato Kohata Yoichiro Asai Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Vladimir V. Kalinichenko Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri
author_facet	Tomohito Izumi Junta Imai Junpei Yamamoto Yohei Kawana Akira Endo Hiroto Sugawara Masato Kohata Yoichiro Asai Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Vladimir V. Kalinichenko Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri
author_sort	Tomohito Izumi
title	Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
title_short	Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
title_full	Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
title_fullStr	Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
title_full_unstemmed	Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
title_sort	vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic foxm1 activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f719e1036e594ff69a5c540261de719c
work_keys_str_mv	AT tomohitoizumi vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT juntaimai vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT junpeiyamamoto vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT yoheikawana vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT akiraendo vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT hirotosugawara vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT masatokohata vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT yoichiroasai vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT keitakahashi vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT shinjirokodama vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT keizokaneko vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT junhonggao vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT kenjiuno vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT shojirosawada vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT vladimirvkalinichenko vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT yasushiishigaki vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT tetsuyayamada vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation AT hidekikatagiri vagusmacrophagehepatocytelinkpromotespostinjuryliverregenerationandwholebodysurvivalthroughhepaticfoxm1activation
_version_	1718380467534692352

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

Ejemplares similares