Defining the root cause of reduced H1N1 live attenuated influenza vaccine effectiveness: low viral fitness leads to inter-strain competition

Abstract In the 2013–14 and 2015–16 influenza seasons, reduced vaccine effectiveness (VE) was observed for the H1N1 component of the FluMist quadrivalent live attenuated influenza vaccine (QLAIV) in the USA, leading to loss of Advisory Committee on Immunization Practices recommendation. Here we demo...

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Bibliographic Details
Main Authors: Oliver Dibben, Jonathan Crowe, Shaun Cooper, Laura Hill, Katarzyna E. Schewe, Helen Bright
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/f71a211b8c824cb3b3b14d74a8b7cf35
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