Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats

Mohammad Yasin Karami,1,2 Nasrin Mansournia,1 Neda Bagherian,3 Alireza Makarem,4 Nader MoeinVaziri,5 Sahar Borna,6 Amir Hossein Pourdavood,7 Iman Shamohammadi4 1Metabolic Disease Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran; 2Breast Disease Research Center,...

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Autores principales:	Karami MY, Mansournia N, Bagherian N, Makarem A, MoeinVaziri N, Borna S, Pourdavood AH, Shamohammadi I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	wound healing azelnidipine stereptozotocin diabetic rat Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/f71a2f41104643adadcf5ee70710a5d2
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spelling	oai:doaj.org-article:f71a2f41104643adadcf5ee70710a5d22021-12-02T03:27:07ZEffects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats2230-2034https://doaj.org/article/f71a2f41104643adadcf5ee70710a5d22019-12-01T00:00:00Zhttps://www.dovepress.com/effects-of-azelnidipine-carboxymethylcellulose-gel-on-healing-of-full--peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Mohammad Yasin Karami,1,2 Nasrin Mansournia,1 Neda Bagherian,3 Alireza Makarem,4 Nader MoeinVaziri,5 Sahar Borna,6 Amir Hossein Pourdavood,7 Iman Shamohammadi4 1Metabolic Disease Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran; 2Breast Disease Research Center, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 3Department of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 4Department of Urology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 5Department of Surgery, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 6Student Research Committee, Faculty of Medicine, Sari University of Medical Sciences, Sari, Iran; 7Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranCorrespondence: Neda BagherianDepartment of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IranTel +98 9177021044Email bagheriannn@gmail.comObjective: To evaluate the effects of azelnidipine-carboxyl methyl cellulose (AZL-CMC) gel and carboxyl methyl cellulose 2% gel (CMC) on the healing of full-thickness skin wounds of diabetic rats.Methods: Fifteen Sprague Dawley male rats were studied. The rats were divided into three groups: AZL-CMC gel-treated, CMC 2% gel-treated, and control group. Wounds were assessed by wound area measurement every 3 days and histopathology samples were collected at 4, 7 and 12 days post wounding to evaluate the healing process using stereological study. Mann–Whitney U-test repeated measurement and non-parametric one-way analysis of variance (ANOVA) were used to analyze the data using SPSS, version 18.Results: Numerical density of the fibroblasts of the AZL-CMC gel treated group was 59.17±2.69 (×104/mm3) and higher than the control 22.64±1.34 (×104/mm3) and CMC 2%-treated groups 40.80±5.27 (×104/mm3), respectively, PConclusion: The healing of AZL-CMC gel-treated wound was better than the control wounds, grossly. Wound healing processes and wound closure in the intervention group began sooner and was completed more quickly. The quantitative and qualitative parameters showed the significant wound healing effect of the AZL-CMC gel-treated group.Keywords: wound healing, azelnidipine, streptozotocin, diabetic, ratKarami MYMansournia NBagherian NMakarem AMoeinVaziri NBorna SPourdavood AHShamohammadi IDove Medical Pressarticlewound healingazelnidipinestereptozotocindiabeticratVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 10, Pp 215-222 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound healing azelnidipine stereptozotocin diabetic rat Veterinary medicine SF600-1100
spellingShingle	wound healing azelnidipine stereptozotocin diabetic rat Veterinary medicine SF600-1100 Karami MY Mansournia N Bagherian N Makarem A MoeinVaziri N Borna S Pourdavood AH Shamohammadi I Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
description	Mohammad Yasin Karami,1,2 Nasrin Mansournia,1 Neda Bagherian,3 Alireza Makarem,4 Nader MoeinVaziri,5 Sahar Borna,6 Amir Hossein Pourdavood,7 Iman Shamohammadi4 1Metabolic Disease Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran; 2Breast Disease Research Center, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 3Department of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 4Department of Urology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 5Department of Surgery, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 6Student Research Committee, Faculty of Medicine, Sari University of Medical Sciences, Sari, Iran; 7Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranCorrespondence: Neda BagherianDepartment of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IranTel +98 9177021044Email bagheriannn@gmail.comObjective: To evaluate the effects of azelnidipine-carboxyl methyl cellulose (AZL-CMC) gel and carboxyl methyl cellulose 2% gel (CMC) on the healing of full-thickness skin wounds of diabetic rats.Methods: Fifteen Sprague Dawley male rats were studied. The rats were divided into three groups: AZL-CMC gel-treated, CMC 2% gel-treated, and control group. Wounds were assessed by wound area measurement every 3 days and histopathology samples were collected at 4, 7 and 12 days post wounding to evaluate the healing process using stereological study. Mann–Whitney U-test repeated measurement and non-parametric one-way analysis of variance (ANOVA) were used to analyze the data using SPSS, version 18.Results: Numerical density of the fibroblasts of the AZL-CMC gel treated group was 59.17±2.69 (×104/mm3) and higher than the control 22.64±1.34 (×104/mm3) and CMC 2%-treated groups 40.80±5.27 (×104/mm3), respectively, PConclusion: The healing of AZL-CMC gel-treated wound was better than the control wounds, grossly. Wound healing processes and wound closure in the intervention group began sooner and was completed more quickly. The quantitative and qualitative parameters showed the significant wound healing effect of the AZL-CMC gel-treated group.Keywords: wound healing, azelnidipine, streptozotocin, diabetic, rat
format	article
author	Karami MY Mansournia N Bagherian N Makarem A MoeinVaziri N Borna S Pourdavood AH Shamohammadi I
author_facet	Karami MY Mansournia N Bagherian N Makarem A MoeinVaziri N Borna S Pourdavood AH Shamohammadi I
author_sort	Karami MY
title	Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
title_short	Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
title_full	Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
title_fullStr	Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
title_full_unstemmed	Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
title_sort	effects of azelnidipine-carboxymethylcellulose gel on healing of full-thickness skin wounds in streptozotocin induced diabetic rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f71a2f41104643adadcf5ee70710a5d2
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Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats

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