Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states

Abstract Stochastic motion on the surface of living cells is critical to promote molecular encounters that are necessary for multiple cellular processes. Often the complexity of the cell membranes leads to anomalous diffusion, which under certain conditions it is accompanied by non-ergodic dynamics....

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Autores principales:	Aleksander Weron, Krzysztof Burnecki, Elizabeth J. Akin, Laura Solé, Michał Balcerek, Michael M. Tamkun, Diego Krapf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f722a179328045ccb65a5d01ad9161a1
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id	oai:doaj.org-article:f722a179328045ccb65a5d01ad9161a1
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spelling	oai:doaj.org-article:f722a179328045ccb65a5d01ad9161a12021-12-02T15:05:44ZErgodicity breaking on the neuronal surface emerges from random switching between diffusive states10.1038/s41598-017-05911-y2045-2322https://doaj.org/article/f722a179328045ccb65a5d01ad9161a12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05911-yhttps://doaj.org/toc/2045-2322Abstract Stochastic motion on the surface of living cells is critical to promote molecular encounters that are necessary for multiple cellular processes. Often the complexity of the cell membranes leads to anomalous diffusion, which under certain conditions it is accompanied by non-ergodic dynamics. Here, we unravel two manifestations of ergodicity breaking in the dynamics of membrane proteins in the somatic surface of hippocampal neurons. Three different tagged molecules are studied on the surface of the soma: the voltage-gated potassium and sodium channels Kv1.4 and Nav1.6 and the glycoprotein CD4. In these three molecules ergodicity breaking is unveiled by the confidence interval of the mean square displacement and by the dynamical functional estimator. Ergodicity breaking is found to take place due to transient confinement effects since the molecules alternate between free diffusion and confined motion.Aleksander WeronKrzysztof BurneckiElizabeth J. AkinLaura SoléMichał BalcerekMichael M. TamkunDiego KrapfNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aleksander Weron Krzysztof Burnecki Elizabeth J. Akin Laura Solé Michał Balcerek Michael M. Tamkun Diego Krapf Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
description	Abstract Stochastic motion on the surface of living cells is critical to promote molecular encounters that are necessary for multiple cellular processes. Often the complexity of the cell membranes leads to anomalous diffusion, which under certain conditions it is accompanied by non-ergodic dynamics. Here, we unravel two manifestations of ergodicity breaking in the dynamics of membrane proteins in the somatic surface of hippocampal neurons. Three different tagged molecules are studied on the surface of the soma: the voltage-gated potassium and sodium channels Kv1.4 and Nav1.6 and the glycoprotein CD4. In these three molecules ergodicity breaking is unveiled by the confidence interval of the mean square displacement and by the dynamical functional estimator. Ergodicity breaking is found to take place due to transient confinement effects since the molecules alternate between free diffusion and confined motion.
format	article
author	Aleksander Weron Krzysztof Burnecki Elizabeth J. Akin Laura Solé Michał Balcerek Michael M. Tamkun Diego Krapf
author_facet	Aleksander Weron Krzysztof Burnecki Elizabeth J. Akin Laura Solé Michał Balcerek Michael M. Tamkun Diego Krapf
author_sort	Aleksander Weron
title	Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
title_short	Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
title_full	Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
title_fullStr	Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
title_full_unstemmed	Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
title_sort	ergodicity breaking on the neuronal surface emerges from random switching between diffusive states
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f722a179328045ccb65a5d01ad9161a1
work_keys_str_mv	AT aleksanderweron ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT krzysztofburnecki ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT elizabethjakin ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT laurasole ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT michałbalcerek ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT michaelmtamkun ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates AT diegokrapf ergodicitybreakingontheneuronalsurfaceemergesfromrandomswitchingbetweendiffusivestates
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Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states

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