RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin

The factors that link chromatin remodelling to nuclear envelope formation in the sperm pronucleus are not fully characterised. Here, the authors show that in RNA-depleted Xenopus laevis egg extracts, ELYS recruitment and nuclear pore complex formation are impaired, resulting in defective nuclear pro...

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Auteurs principaux: Antoine Aze, Michalis Fragkos, Stéphane Bocquet, Julien Cau, Marcel Méchali
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/f725bd91ed4b47498e998da3b6cefc50
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Résumé:The factors that link chromatin remodelling to nuclear envelope formation in the sperm pronucleus are not fully characterised. Here, the authors show that in RNA-depleted Xenopus laevis egg extracts, ELYS recruitment and nuclear pore complex formation are impaired, resulting in defective nuclear processes.