Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study

Abstract To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in cynomogulus macaque monkey model following increase in intraocular pressure by an intravitreal injection....

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Autores principales:	Chui Ming Gemmy Cheung, Kelvin Yi Chong Teo, Sai Bo Bo Tun, Joanna Marie Busoy, Amutha Barathi Veluchamy, Richard F. Spaide
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f727c12791c3457b9347d1165becef7f
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spelling	oai:doaj.org-article:f727c12791c3457b9347d1165becef7f2021-12-02T18:37:06ZDifferential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study10.1038/s41598-020-73585-02045-2322https://doaj.org/article/f727c12791c3457b9347d1165becef7f2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73585-0https://doaj.org/toc/2045-2322Abstract To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in cynomogulus macaque monkey model following increase in intraocular pressure by an intravitreal injection. Animal imaging study. Two cynomogulus macaque monkeys. A 100 µL intravitreal injection (IVI) of saline was given in one eye of each monkey. Serial OCTA using a Zeiss Plex Elite 9000 was used to evaluate reperfusion patterns within the SCP, DCP, and CC. OCTA evidence of perfusion. Pulsation of the central retinal artery was detected after the intraocular pressure was elevated to 98 and ≥ 99 mmHg from IVI. Episodic flow within the SVP arterioles and venules and poor visualization of flow in capillaries was noted during the initial phase of elevated pressure. As the pressure declined, the flow signal within the DCP appeared initially as dots, which progressed laterally to loops which form capillary vortex configuration. Recovery of flow within the SVP and CC appeared sooner than in the DCP. At 40 min after the injection, well after the intraocular pressure normalized, the retinal and choriocapillaris vascular perfusion showed focal defects in every layer. Compared with pre-injection images, vessel density in the DCP was 68.8% and 78.6% of baseline in monkey 1 and monkey 2, respectively. In contrast vessel density in the SVP recovered to 84.2% and 88.9% of baseline. Increases in intraocular pressure from IVI have the potential to affect every layer of blood flow in the fundus. After nominal return of intraocular pressure, focal defects in flow persisted, which may result in longer term damage to the retina.Chui Ming Gemmy CheungKelvin Yi Chong TeoSai Bo Bo TunJoanna Marie BusoyAmutha Barathi VeluchamyRichard F. SpaideNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Amutha Barathi Veluchamy Richard F. Spaide Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
description	Abstract To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in cynomogulus macaque monkey model following increase in intraocular pressure by an intravitreal injection. Animal imaging study. Two cynomogulus macaque monkeys. A 100 µL intravitreal injection (IVI) of saline was given in one eye of each monkey. Serial OCTA using a Zeiss Plex Elite 9000 was used to evaluate reperfusion patterns within the SCP, DCP, and CC. OCTA evidence of perfusion. Pulsation of the central retinal artery was detected after the intraocular pressure was elevated to 98 and ≥ 99 mmHg from IVI. Episodic flow within the SVP arterioles and venules and poor visualization of flow in capillaries was noted during the initial phase of elevated pressure. As the pressure declined, the flow signal within the DCP appeared initially as dots, which progressed laterally to loops which form capillary vortex configuration. Recovery of flow within the SVP and CC appeared sooner than in the DCP. At 40 min after the injection, well after the intraocular pressure normalized, the retinal and choriocapillaris vascular perfusion showed focal defects in every layer. Compared with pre-injection images, vessel density in the DCP was 68.8% and 78.6% of baseline in monkey 1 and monkey 2, respectively. In contrast vessel density in the SVP recovered to 84.2% and 88.9% of baseline. Increases in intraocular pressure from IVI have the potential to affect every layer of blood flow in the fundus. After nominal return of intraocular pressure, focal defects in flow persisted, which may result in longer term damage to the retina.
format	article
author	Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Amutha Barathi Veluchamy Richard F. Spaide
author_facet	Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Amutha Barathi Veluchamy Richard F. Spaide
author_sort	Chui Ming Gemmy Cheung
title	Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
title_short	Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
title_full	Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
title_fullStr	Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
title_full_unstemmed	Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
title_sort	differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an oct angiography study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f727c12791c3457b9347d1165becef7f
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Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study

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