Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression

It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotyp...

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Autores principales:	William W. Greenwald, He Li, Paola Benaglio, David Jakubosky, Hiroko Matsui, Anthony Schmitt, Siddarth Selvaraj, Matteo D’Antonio, Agnieszka D’Antonio-Chronowska, Erin N. Smith, Kelly A. Frazer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f72b1213a233451aa67b2d6cb89c60be
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spelling	oai:doaj.org-article:f72b1213a233451aa67b2d6cb89c60be2021-12-02T15:35:57ZSubtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression10.1038/s41467-019-08940-52041-1723https://doaj.org/article/f72b1213a233451aa67b2d6cb89c60be2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08940-5https://doaj.org/toc/2041-1723It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotypes.William W. GreenwaldHe LiPaola BenaglioDavid JakuboskyHiroko MatsuiAnthony SchmittSiddarth SelvarajMatteo D’AntonioAgnieszka D’Antonio-ChronowskaErin N. SmithKelly A. FrazerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
description	It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotypes.
format	article
author	William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer
author_facet	William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer
author_sort	William W. Greenwald
title	Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
title_short	Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
title_full	Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
title_fullStr	Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
title_full_unstemmed	Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
title_sort	subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f72b1213a233451aa67b2d6cb89c60be
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Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression

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