Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.

<h4>Background</h4>Although diarrheal illnesses are recognized as both a cause and effect of undernutrition, evidence for the effect of specific enteropathogens on early childhood growth remains limited. We estimated the effects of undernutrition as a risk factor for campylobacteriosis,...

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Autores principales:	Gwenyth Lee, William Pan, Pablo Peñataro Yori, Maribel Paredes Olortegui, Drake Tilley, Michael Gregory, Richard Oberhelman, Rosa Burga, Cesar Banda Chavez, Margaret Kosek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f72d3af16ef64a3a8601cf830599b6f2
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spelling	oai:doaj.org-article:f72d3af16ef64a3a8601cf830599b6f22021-11-18T09:15:24ZSymptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.1935-27271935-273510.1371/journal.pntd.0002036https://doaj.org/article/f72d3af16ef64a3a8601cf830599b6f22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23383356/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Although diarrheal illnesses are recognized as both a cause and effect of undernutrition, evidence for the effect of specific enteropathogens on early childhood growth remains limited. We estimated the effects of undernutrition as a risk factor for campylobacteriosis, as well as associations between symptomatic and asymptomatic Campylobacter infections and growth.<h4>Methodology/principal findings</h4>Using data from a prospective cohort of 442 children aged 0-72 months, the effect of nutritional status on the incidence of Campylobacter infection was estimated using uni- and multivariate Poisson models. Multivariate regression models were developed to evaluate the effect of Campylobacter infection on weight gain and linear growth. Overall, 8.3% of diarrheal episodes were associated with Campylobacter (crude incidence rate = 0.37 episodes/year) and 4.9% of quarterly asymptomatic samples were Campylobacter positive. In univariate models, the incidence of Campylobacter infection was marginally higher in stunted than non-stunted children (IRR 1.270, 95% CI (0.960, 1.681)(p = 0.095). When recent diarrheal burdens were included in the analysis, there was no difference in risk between stunted and unstunted children. Asymptomatic and symptomatic Campylobacter infections were associated with reduced weight gain over a three-month period (65.5 g (95% CI: -128.0, -3.0)(p = 0.040) and 43.9 g (95% CI:-87.6, -1.0)(p = 0.049) less weight gain, respectively). Symptomatic Campylobacter infections were only marginally associated with reduced linear growth over a nine month period (-0.059 cm per episode, 95% CI: -0.118, 0.001)(p = 0.054), however relatively severe episodes were associated with reduced linear growth (-0.169 cm/episode, 95% CI -0.310, -0.028)(p = 0.019).<h4>Conclusions/significance</h4>Our findings suggest that Campylobacter is not as benign as commonly assumed, and that there is evidence to support expanding the indications for antibiotic therapy in campylobacteriosis in children.Gwenyth LeeWilliam PanPablo Peñataro YoriMaribel Paredes OlorteguiDrake TilleyMichael GregoryRichard OberhelmanRosa BurgaCesar Banda ChavezMargaret KosekPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 7, Iss 1, p e2036 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gwenyth Lee William Pan Pablo Peñataro Yori Maribel Paredes Olortegui Drake Tilley Michael Gregory Richard Oberhelman Rosa Burga Cesar Banda Chavez Margaret Kosek Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
description	<h4>Background</h4>Although diarrheal illnesses are recognized as both a cause and effect of undernutrition, evidence for the effect of specific enteropathogens on early childhood growth remains limited. We estimated the effects of undernutrition as a risk factor for campylobacteriosis, as well as associations between symptomatic and asymptomatic Campylobacter infections and growth.<h4>Methodology/principal findings</h4>Using data from a prospective cohort of 442 children aged 0-72 months, the effect of nutritional status on the incidence of Campylobacter infection was estimated using uni- and multivariate Poisson models. Multivariate regression models were developed to evaluate the effect of Campylobacter infection on weight gain and linear growth. Overall, 8.3% of diarrheal episodes were associated with Campylobacter (crude incidence rate = 0.37 episodes/year) and 4.9% of quarterly asymptomatic samples were Campylobacter positive. In univariate models, the incidence of Campylobacter infection was marginally higher in stunted than non-stunted children (IRR 1.270, 95% CI (0.960, 1.681)(p = 0.095). When recent diarrheal burdens were included in the analysis, there was no difference in risk between stunted and unstunted children. Asymptomatic and symptomatic Campylobacter infections were associated with reduced weight gain over a three-month period (65.5 g (95% CI: -128.0, -3.0)(p = 0.040) and 43.9 g (95% CI:-87.6, -1.0)(p = 0.049) less weight gain, respectively). Symptomatic Campylobacter infections were only marginally associated with reduced linear growth over a nine month period (-0.059 cm per episode, 95% CI: -0.118, 0.001)(p = 0.054), however relatively severe episodes were associated with reduced linear growth (-0.169 cm/episode, 95% CI -0.310, -0.028)(p = 0.019).<h4>Conclusions/significance</h4>Our findings suggest that Campylobacter is not as benign as commonly assumed, and that there is evidence to support expanding the indications for antibiotic therapy in campylobacteriosis in children.
format	article
author	Gwenyth Lee William Pan Pablo Peñataro Yori Maribel Paredes Olortegui Drake Tilley Michael Gregory Richard Oberhelman Rosa Burga Cesar Banda Chavez Margaret Kosek
author_facet	Gwenyth Lee William Pan Pablo Peñataro Yori Maribel Paredes Olortegui Drake Tilley Michael Gregory Richard Oberhelman Rosa Burga Cesar Banda Chavez Margaret Kosek
author_sort	Gwenyth Lee
title	Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
title_short	Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
title_full	Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
title_fullStr	Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
title_full_unstemmed	Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.
title_sort	symptomatic and asymptomatic campylobacter infections associated with reduced growth in peruvian children.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f72d3af16ef64a3a8601cf830599b6f2
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Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in Peruvian children.

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