The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating mitochondrial respiration via Fam3a.

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Autores principales:	David Sala, Thomas J. Cunningham, Michael J. Stec, Usue Etxaniz, Chiara Nicoletti, Alessandra Dall’Agnese, Pier Lorenzo Puri, Gregg Duester, Lucia Latella, Alessandra Sacco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f73043aa60404babb39cc98df4240817
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spelling	oai:doaj.org-article:f73043aa60404babb39cc98df42408172021-12-02T14:35:50ZThe Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration10.1038/s41467-019-09746-12041-1723https://doaj.org/article/f73043aa60404babb39cc98df42408172019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09746-1https://doaj.org/toc/2041-1723Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating mitochondrial respiration via Fam3a.David SalaThomas J. CunninghamMichael J. StecUsue EtxanizChiara NicolettiAlessandra Dall’AgnesePier Lorenzo PuriGregg DuesterLucia LatellaAlessandra SaccoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Sala Thomas J. Cunningham Michael J. Stec Usue Etxaniz Chiara Nicoletti Alessandra Dall’Agnese Pier Lorenzo Puri Gregg Duester Lucia Latella Alessandra Sacco The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
description	Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating mitochondrial respiration via Fam3a.
format	article
author	David Sala Thomas J. Cunningham Michael J. Stec Usue Etxaniz Chiara Nicoletti Alessandra Dall’Agnese Pier Lorenzo Puri Gregg Duester Lucia Latella Alessandra Sacco
author_facet	David Sala Thomas J. Cunningham Michael J. Stec Usue Etxaniz Chiara Nicoletti Alessandra Dall’Agnese Pier Lorenzo Puri Gregg Duester Lucia Latella Alessandra Sacco
author_sort	David Sala
title	The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
title_short	The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
title_full	The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
title_fullStr	The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
title_full_unstemmed	The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
title_sort	stat3-fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f73043aa60404babb39cc98df4240817
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The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

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