Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.

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Autores principales:	Adriana I. Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N. Cooke Bailey, Colin E. Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P. Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L. Haines, Lisa S. Kearns, Caroline Hayward, Yuan Shi, Elisabeth M. van Leeuwen, Kent D. Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I. Rotter, Nicholas G. Martin, Tanja Zeller, Richard A. Mills, Emmanuelle Souzeau, Sandra E. Staffieri, Jost B. Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H. Kang, Sionne E. M. Lucas, Tien Yin Wong, Manfred E. Beutel, James F. Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G. Uitterlinden, Eranga N. Vithana, Paul J. Foster, Pirro G. Hysi, Alex W. Hewitt, Chiea Chuen Khor, Louis R. Pasquale, Grant W. Montgomery, Caroline C. W. Klaver, Tin Aung, Norbert Pfeiffer, David A. Mackey, Christopher J. Hammond, Ching-Yu Cheng, Jamie E. Craig, Yaron S. Rabinowitz, Janey L. Wiggs, Kathryn P. Burdon, Cornelia M. van Duijn, Stuart MacGregor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7334f0a8f8b42b18a3180c2a6650fb9
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spelling	oai:doaj.org-article:f7334f0a8f8b42b18a3180c2a6650fb92021-12-02T15:33:36ZCross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases10.1038/s41467-018-03646-62041-1723https://doaj.org/article/f7334f0a8f8b42b18a3180c2a6650fb92018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03646-6https://doaj.org/toc/2041-1723Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.Adriana I. IglesiasAniket MishraVeronique VitartYelena BykhovskayaRené HöhnHenriët SpringelkampGabriel Cuellar-PartidaPuya GharahkhaniJessica N. Cooke BaileyColin E. WilloughbyXiaohui LiSeyhan YazarAbhishek NagAnthony P. KhawajaOzren PolašekDavid SiscovickPaul MitchellYih Chung ThamJonathan L. HainesLisa S. KearnsCaroline HaywardYuan ShiElisabeth M. van LeeuwenKent D. TaylorBlue Mountains Eye Study—GWAS groupPieter BonnemaijerJerome I. RotterNicholas G. MartinTanja ZellerRichard A. MillsEmmanuelle SouzeauSandra E. StaffieriJost B. JonasIrene SchmidtmannThibaud BoutinJae H. KangSionne E. M. LucasTien Yin WongManfred E. BeutelJames F. WilsonNEIGHBORHOOD ConsortiumWellcome Trust Case Control Consortium 2 (WTCCC2)André G. UitterlindenEranga N. VithanaPaul J. FosterPirro G. HysiAlex W. HewittChiea Chuen KhorLouis R. PasqualeGrant W. MontgomeryCaroline C. W. KlaverTin AungNorbert PfeifferDavid A. MackeyChristopher J. HammondChing-Yu ChengJamie E. CraigYaron S. RabinowitzJaney L. WiggsKathryn P. BurdonCornelia M. van DuijnStuart MacGregorNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adriana I. Iglesias Aniket Mishra Veronique Vitart Yelena Bykhovskaya René Höhn Henriët Springelkamp Gabriel Cuellar-Partida Puya Gharahkhani Jessica N. Cooke Bailey Colin E. Willoughby Xiaohui Li Seyhan Yazar Abhishek Nag Anthony P. Khawaja Ozren Polašek David Siscovick Paul Mitchell Yih Chung Tham Jonathan L. Haines Lisa S. Kearns Caroline Hayward Yuan Shi Elisabeth M. van Leeuwen Kent D. Taylor Blue Mountains Eye Study—GWAS group Pieter Bonnemaijer Jerome I. Rotter Nicholas G. Martin Tanja Zeller Richard A. Mills Emmanuelle Souzeau Sandra E. Staffieri Jost B. Jonas Irene Schmidtmann Thibaud Boutin Jae H. Kang Sionne E. M. Lucas Tien Yin Wong Manfred E. Beutel James F. Wilson NEIGHBORHOOD Consortium Wellcome Trust Case Control Consortium 2 (WTCCC2) André G. Uitterlinden Eranga N. Vithana Paul J. Foster Pirro G. Hysi Alex W. Hewitt Chiea Chuen Khor Louis R. Pasquale Grant W. Montgomery Caroline C. W. Klaver Tin Aung Norbert Pfeiffer David A. Mackey Christopher J. Hammond Ching-Yu Cheng Jamie E. Craig Yaron S. Rabinowitz Janey L. Wiggs Kathryn P. Burdon Cornelia M. van Duijn Stuart MacGregor Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
description	Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.
format	article
author	Adriana I. Iglesias Aniket Mishra Veronique Vitart Yelena Bykhovskaya René Höhn Henriët Springelkamp Gabriel Cuellar-Partida Puya Gharahkhani Jessica N. Cooke Bailey Colin E. Willoughby Xiaohui Li Seyhan Yazar Abhishek Nag Anthony P. Khawaja Ozren Polašek David Siscovick Paul Mitchell Yih Chung Tham Jonathan L. Haines Lisa S. Kearns Caroline Hayward Yuan Shi Elisabeth M. van Leeuwen Kent D. Taylor Blue Mountains Eye Study—GWAS group Pieter Bonnemaijer Jerome I. Rotter Nicholas G. Martin Tanja Zeller Richard A. Mills Emmanuelle Souzeau Sandra E. Staffieri Jost B. Jonas Irene Schmidtmann Thibaud Boutin Jae H. Kang Sionne E. M. Lucas Tien Yin Wong Manfred E. Beutel James F. Wilson NEIGHBORHOOD Consortium Wellcome Trust Case Control Consortium 2 (WTCCC2) André G. Uitterlinden Eranga N. Vithana Paul J. Foster Pirro G. Hysi Alex W. Hewitt Chiea Chuen Khor Louis R. Pasquale Grant W. Montgomery Caroline C. W. Klaver Tin Aung Norbert Pfeiffer David A. Mackey Christopher J. Hammond Ching-Yu Cheng Jamie E. Craig Yaron S. Rabinowitz Janey L. Wiggs Kathryn P. Burdon Cornelia M. van Duijn Stuart MacGregor
author_facet	Adriana I. Iglesias Aniket Mishra Veronique Vitart Yelena Bykhovskaya René Höhn Henriët Springelkamp Gabriel Cuellar-Partida Puya Gharahkhani Jessica N. Cooke Bailey Colin E. Willoughby Xiaohui Li Seyhan Yazar Abhishek Nag Anthony P. Khawaja Ozren Polašek David Siscovick Paul Mitchell Yih Chung Tham Jonathan L. Haines Lisa S. Kearns Caroline Hayward Yuan Shi Elisabeth M. van Leeuwen Kent D. Taylor Blue Mountains Eye Study—GWAS group Pieter Bonnemaijer Jerome I. Rotter Nicholas G. Martin Tanja Zeller Richard A. Mills Emmanuelle Souzeau Sandra E. Staffieri Jost B. Jonas Irene Schmidtmann Thibaud Boutin Jae H. Kang Sionne E. M. Lucas Tien Yin Wong Manfred E. Beutel James F. Wilson NEIGHBORHOOD Consortium Wellcome Trust Case Control Consortium 2 (WTCCC2) André G. Uitterlinden Eranga N. Vithana Paul J. Foster Pirro G. Hysi Alex W. Hewitt Chiea Chuen Khor Louis R. Pasquale Grant W. Montgomery Caroline C. W. Klaver Tin Aung Norbert Pfeiffer David A. Mackey Christopher J. Hammond Ching-Yu Cheng Jamie E. Craig Yaron S. Rabinowitz Janey L. Wiggs Kathryn P. Burdon Cornelia M. van Duijn Stuart MacGregor
author_sort	Adriana I. Iglesias
title	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_short	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_full	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_fullStr	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_full_unstemmed	Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
title_sort	cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and mendelian eye diseases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f7334f0a8f8b42b18a3180c2a6650fb9
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Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

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