Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke

Abstract Stroke leads to both regional brain functional disruptions and network reorganization. However, how brain functional networks reconfigure as task demand increases in stroke patients and whether such reorganization at baseline would facilitate post-stroke motor recovery are largely unknown....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hsiao-Ju Cheng, Kwun Kei Ng, Xing Qian, Fang Ji, Zhong Kang Lu, Wei Peng Teo, Xin Hong, Fatima Ali Nasrallah, Kai Keng Ang, Kai-Hsiang Chuang, Cuntai Guan, Haoyong Yu, Effie Chew, Juan Helen Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7337ab9f78b431a8293160fb3fb5b78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7337ab9f78b431a8293160fb3fb5b78
record_format	dspace
spelling	oai:doaj.org-article:f7337ab9f78b431a8293160fb3fb5b782021-12-02T16:45:46ZTask-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke10.1038/s41598-021-87789-52045-2322https://doaj.org/article/f7337ab9f78b431a8293160fb3fb5b782021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87789-5https://doaj.org/toc/2045-2322Abstract Stroke leads to both regional brain functional disruptions and network reorganization. However, how brain functional networks reconfigure as task demand increases in stroke patients and whether such reorganization at baseline would facilitate post-stroke motor recovery are largely unknown. To address this gap, brain functional connectivity (FC) were examined at rest and motor tasks in eighteen chronic subcortical stroke patients and eleven age-matched healthy controls. Stroke patients underwent a 2-week intervention using a motor imagery-assisted brain computer interface-based (MI-BCI) training with or without transcranial direct current stimulation (tDCS). Motor recovery was determined by calculating the changes of the upper extremity component of the Fugl–Meyer Assessment (FMA) score between pre- and post-intervention divided by the pre-intervention FMA score. The results suggested that as task demand increased (i.e., from resting to passive unaffected hand gripping and to active affected hand gripping), patients showed greater FC disruptions in cognitive networks including the default and dorsal attention networks. Compared to controls, patients had lower task-related spatial similarity in the somatomotor–subcortical, default–somatomotor, salience/ventral attention–subcortical and subcortical–subcortical connections, suggesting greater inefficiency in motor execution. Importantly, higher baseline network-specific FC strength (e.g., dorsal attention and somatomotor) and more efficient brain network reconfigurations (e.g., somatomotor and subcortical) from rest to active affected hand gripping at baseline were related to better future motor recovery. Our findings underscore the importance of studying functional network reorganization during task-free and task conditions for motor recovery prediction in stroke.Hsiao-Ju ChengKwun Kei NgXing QianFang JiZhong Kang LuWei Peng TeoXin HongFatima Ali NasrallahKai Keng AngKai-Hsiang ChuangCuntai GuanHaoyong YuEffie ChewJuan Helen ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsiao-Ju Cheng Kwun Kei Ng Xing Qian Fang Ji Zhong Kang Lu Wei Peng Teo Xin Hong Fatima Ali Nasrallah Kai Keng Ang Kai-Hsiang Chuang Cuntai Guan Haoyong Yu Effie Chew Juan Helen Zhou Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
description	Abstract Stroke leads to both regional brain functional disruptions and network reorganization. However, how brain functional networks reconfigure as task demand increases in stroke patients and whether such reorganization at baseline would facilitate post-stroke motor recovery are largely unknown. To address this gap, brain functional connectivity (FC) were examined at rest and motor tasks in eighteen chronic subcortical stroke patients and eleven age-matched healthy controls. Stroke patients underwent a 2-week intervention using a motor imagery-assisted brain computer interface-based (MI-BCI) training with or without transcranial direct current stimulation (tDCS). Motor recovery was determined by calculating the changes of the upper extremity component of the Fugl–Meyer Assessment (FMA) score between pre- and post-intervention divided by the pre-intervention FMA score. The results suggested that as task demand increased (i.e., from resting to passive unaffected hand gripping and to active affected hand gripping), patients showed greater FC disruptions in cognitive networks including the default and dorsal attention networks. Compared to controls, patients had lower task-related spatial similarity in the somatomotor–subcortical, default–somatomotor, salience/ventral attention–subcortical and subcortical–subcortical connections, suggesting greater inefficiency in motor execution. Importantly, higher baseline network-specific FC strength (e.g., dorsal attention and somatomotor) and more efficient brain network reconfigurations (e.g., somatomotor and subcortical) from rest to active affected hand gripping at baseline were related to better future motor recovery. Our findings underscore the importance of studying functional network reorganization during task-free and task conditions for motor recovery prediction in stroke.
format	article
author	Hsiao-Ju Cheng Kwun Kei Ng Xing Qian Fang Ji Zhong Kang Lu Wei Peng Teo Xin Hong Fatima Ali Nasrallah Kai Keng Ang Kai-Hsiang Chuang Cuntai Guan Haoyong Yu Effie Chew Juan Helen Zhou
author_facet	Hsiao-Ju Cheng Kwun Kei Ng Xing Qian Fang Ji Zhong Kang Lu Wei Peng Teo Xin Hong Fatima Ali Nasrallah Kai Keng Ang Kai-Hsiang Chuang Cuntai Guan Haoyong Yu Effie Chew Juan Helen Zhou
author_sort	Hsiao-Ju Cheng
title	Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
title_short	Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
title_full	Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
title_fullStr	Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
title_full_unstemmed	Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
title_sort	task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7337ab9f78b431a8293160fb3fb5b78
work_keys_str_mv	AT hsiaojucheng taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT kwunkeing taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT xingqian taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT fangji taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT zhongkanglu taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT weipengteo taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT xinhong taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT fatimaalinasrallah taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT kaikengang taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT kaihsiangchuang taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT cuntaiguan taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT haoyongyu taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT effiechew taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke AT juanhelenzhou taskrelatedbrainfunctionalnetworkreconfigurationsrelatetomotorrecoveryinchronicsubcorticalstroke
_version_	1718383492020043776

Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke

Ejemplares similares