Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.

Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific freque...

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Autores principales:	Rongjun Yu, Ming H Hsieh, Hsiao-Lan Sharon Wang, Chih-Min Liu, Chen-Chung Liu, Tzung-Jeng Hwang, Yi-Ling Chien, Hai-Gwo Hwu, Wen-Yih Isaac Tseng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7369192c0114f9bb647a47ac96c81c8
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spelling	oai:doaj.org-article:f7369192c0114f9bb647a47ac96c81c82021-11-18T07:54:42ZFrequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.1932-620310.1371/journal.pone.0057516https://doaj.org/article/f7369192c0114f9bb647a47ac96c81c82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23483911/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5:0.01-0.027 Hz; slow-4:0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. Compared with controls, schizophrenia patients exhibited decreased ReHo in the precentral gyrus, middle occipital gyrus, and posterior insula, whereas increased ReHo in the medial prefrontal cortex and anterior insula. Significant differences in ReHo between the two bands were found in fusiform gyrus and superior frontal gyrus (slow-4> slow-5), and in basal ganglia, parahippocampus, and dorsal middle prefrontal gyrus (slow-5> slow-4). Importantly, we identified significant interaction between frequency bands and groups in the inferior occipital gyrus and caudate body. This study demonstrates that ReHo changes in schizophrenia are widespread and frequency dependent.Rongjun YuMing H HsiehHsiao-Lan Sharon WangChih-Min LiuChen-Chung LiuTzung-Jeng HwangYi-Ling ChienHai-Gwo HwuWen-Yih Isaac TsengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57516 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rongjun Yu Ming H Hsieh Hsiao-Lan Sharon Wang Chih-Min Liu Chen-Chung Liu Tzung-Jeng Hwang Yi-Ling Chien Hai-Gwo Hwu Wen-Yih Isaac Tseng Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
description	Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5:0.01-0.027 Hz; slow-4:0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. Compared with controls, schizophrenia patients exhibited decreased ReHo in the precentral gyrus, middle occipital gyrus, and posterior insula, whereas increased ReHo in the medial prefrontal cortex and anterior insula. Significant differences in ReHo between the two bands were found in fusiform gyrus and superior frontal gyrus (slow-4> slow-5), and in basal ganglia, parahippocampus, and dorsal middle prefrontal gyrus (slow-5> slow-4). Importantly, we identified significant interaction between frequency bands and groups in the inferior occipital gyrus and caudate body. This study demonstrates that ReHo changes in schizophrenia are widespread and frequency dependent.
format	article
author	Rongjun Yu Ming H Hsieh Hsiao-Lan Sharon Wang Chih-Min Liu Chen-Chung Liu Tzung-Jeng Hwang Yi-Ling Chien Hai-Gwo Hwu Wen-Yih Isaac Tseng
author_facet	Rongjun Yu Ming H Hsieh Hsiao-Lan Sharon Wang Chih-Min Liu Chen-Chung Liu Tzung-Jeng Hwang Yi-Ling Chien Hai-Gwo Hwu Wen-Yih Isaac Tseng
author_sort	Rongjun Yu
title	Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
title_short	Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
title_full	Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
title_fullStr	Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
title_full_unstemmed	Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
title_sort	frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f7369192c0114f9bb647a47ac96c81c8
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Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia.

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