Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

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Large-scale genomic alterations play an important role in disease, gene expression, and chromosome evolution. Optical DNA mapping (ODM), commonly categorized into sparsely-labelled ODM and densely-labelled ODM, provides sequence-specific continuous intensity profiles (DNA barcodes) along single DNA...

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Autores principales: Albertas Dvirnas, Callum Stewart, Vilhelm Müller, Santosh Kumar Bikkarolla, Karolin Frykholm, Linus Sandegren, Erik Kristiansson, Fredrik Westerlund, Tobias Ambjörnsson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f736f01fc2a246668e1812109bd1bf44
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