Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential

Extracellular vesicles (EVs) mediate intercellular communication by transferring genetic material, proteins and organelles between different cells types in both health and disease. Recent evidence suggests that these vesicles, more than simply diagnostic markers, are key mediators of the pathophysio...

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Autores principales:	Sergio Esquivel-Ruiz, Paloma González-Rodríguez, José A. Lorente, Francisco Pérez-Vizcaíno, Raquel Herrero, Laura Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	barrier dysfunction airway epithelium pulmonary endothelium mesenchymal stem cells extracellular vesicles (EVs) preconditioning Physiology QP1-981
Acceso en línea:	https://doaj.org/article/f739e7595b4949fa9b2b6ee7cf0c5ccd
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spelling	oai:doaj.org-article:f739e7595b4949fa9b2b6ee7cf0c5ccd2021-11-30T13:45:18ZExtracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential1664-042X10.3389/fphys.2021.752287https://doaj.org/article/f739e7595b4949fa9b2b6ee7cf0c5ccd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.752287/fullhttps://doaj.org/toc/1664-042XExtracellular vesicles (EVs) mediate intercellular communication by transferring genetic material, proteins and organelles between different cells types in both health and disease. Recent evidence suggests that these vesicles, more than simply diagnostic markers, are key mediators of the pathophysiology of acute respiratory distress syndrome (ARDS) and other lung diseases. In this review, we will discuss the contribution of EVs released by pulmonary structural cells (alveolar epithelial and endothelial cells) and immune cells in these diseases, with particular attention to their ability to modulate inflammation and alveolar-capillary barrier disruption, a hallmark of ARDS. EVs also offer a unique opportunity to develop new therapeutics for the treatment of ARDS. Evidences supporting the ability of stem cell-derived EVs to attenuate the lung injury and ongoing strategies to improve their therapeutic potential are also discussed.Sergio Esquivel-RuizSergio Esquivel-RuizPaloma González-RodríguezPaloma González-RodríguezJosé A. LorenteJosé A. LorenteJosé A. LorenteFrancisco Pérez-VizcaínoFrancisco Pérez-VizcaínoRaquel HerreroRaquel HerreroLaura MorenoLaura MorenoFrontiers Media S.A.articlebarrier dysfunctionairway epitheliumpulmonary endotheliummesenchymal stem cellsextracellular vesicles (EVs)preconditioningPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	barrier dysfunction airway epithelium pulmonary endothelium mesenchymal stem cells extracellular vesicles (EVs) preconditioning Physiology QP1-981
spellingShingle	barrier dysfunction airway epithelium pulmonary endothelium mesenchymal stem cells extracellular vesicles (EVs) preconditioning Physiology QP1-981 Sergio Esquivel-Ruiz Sergio Esquivel-Ruiz Paloma González-Rodríguez Paloma González-Rodríguez José A. Lorente José A. Lorente José A. Lorente Francisco Pérez-Vizcaíno Francisco Pérez-Vizcaíno Raquel Herrero Raquel Herrero Laura Moreno Laura Moreno Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
description	Extracellular vesicles (EVs) mediate intercellular communication by transferring genetic material, proteins and organelles between different cells types in both health and disease. Recent evidence suggests that these vesicles, more than simply diagnostic markers, are key mediators of the pathophysiology of acute respiratory distress syndrome (ARDS) and other lung diseases. In this review, we will discuss the contribution of EVs released by pulmonary structural cells (alveolar epithelial and endothelial cells) and immune cells in these diseases, with particular attention to their ability to modulate inflammation and alveolar-capillary barrier disruption, a hallmark of ARDS. EVs also offer a unique opportunity to develop new therapeutics for the treatment of ARDS. Evidences supporting the ability of stem cell-derived EVs to attenuate the lung injury and ongoing strategies to improve their therapeutic potential are also discussed.
format	article
author	Sergio Esquivel-Ruiz Sergio Esquivel-Ruiz Paloma González-Rodríguez Paloma González-Rodríguez José A. Lorente José A. Lorente José A. Lorente Francisco Pérez-Vizcaíno Francisco Pérez-Vizcaíno Raquel Herrero Raquel Herrero Laura Moreno Laura Moreno
author_facet	Sergio Esquivel-Ruiz Sergio Esquivel-Ruiz Paloma González-Rodríguez Paloma González-Rodríguez José A. Lorente José A. Lorente José A. Lorente Francisco Pérez-Vizcaíno Francisco Pérez-Vizcaíno Raquel Herrero Raquel Herrero Laura Moreno Laura Moreno
author_sort	Sergio Esquivel-Ruiz
title	Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
title_short	Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
title_full	Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
title_fullStr	Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
title_full_unstemmed	Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential
title_sort	extracellular vesicles and alveolar epithelial-capillary barrier disruption in acute respiratory distress syndrome: pathophysiological role and therapeutic potential
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f739e7595b4949fa9b2b6ee7cf0c5ccd
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Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential

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