Platelet-rich fibrin: Basics of biological actions and protocol modifications

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, t...

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Autores principales:	Pavlovic Voja, Ciric Milan, Jovanovic Vladimir, Trandafilovic Milena, Stojanovic Predrag
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	platelet-rich fibrin platelets growth factors wound healing Medicine R
Acceso en línea:	https://doaj.org/article/f73a414ac17947968aa511c75ef726e8
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spelling	oai:doaj.org-article:f73a414ac17947968aa511c75ef726e82021-12-05T14:10:54ZPlatelet-rich fibrin: Basics of biological actions and protocol modifications2391-546310.1515/med-2021-0259https://doaj.org/article/f73a414ac17947968aa511c75ef726e82021-03-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0259https://doaj.org/toc/2391-5463Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components and to provide insight into the new developmental approach. Also, this review summarizes the evolution of platelet concentrates and biologic properties of different modifications of PRF procedure.Pavlovic VojaCiric MilanJovanovic VladimirTrandafilovic MilenaStojanovic PredragDe Gruyterarticleplatelet-rich fibrinplateletsgrowth factorswound healingMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 446-454 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet-rich fibrin platelets growth factors wound healing Medicine R
spellingShingle	platelet-rich fibrin platelets growth factors wound healing Medicine R Pavlovic Voja Ciric Milan Jovanovic Vladimir Trandafilovic Milena Stojanovic Predrag Platelet-rich fibrin: Basics of biological actions and protocol modifications
description	Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other advantages over traditionally prepared platelet concentrates. Since its introduction, various protocols for PRF preparation have been proposed with different amounts of growth factors and other biomolecules necessary for wound healing. However, reference data about potential effect of some PRF components on hard and soft tissue healing are still conflicting. The current article intends to clarify the relevant advances about physiological role of certain PRF components and to provide insight into the new developmental approach. Also, this review summarizes the evolution of platelet concentrates and biologic properties of different modifications of PRF procedure.
format	article
author	Pavlovic Voja Ciric Milan Jovanovic Vladimir Trandafilovic Milena Stojanovic Predrag
author_facet	Pavlovic Voja Ciric Milan Jovanovic Vladimir Trandafilovic Milena Stojanovic Predrag
author_sort	Pavlovic Voja
title	Platelet-rich fibrin: Basics of biological actions and protocol modifications
title_short	Platelet-rich fibrin: Basics of biological actions and protocol modifications
title_full	Platelet-rich fibrin: Basics of biological actions and protocol modifications
title_fullStr	Platelet-rich fibrin: Basics of biological actions and protocol modifications
title_full_unstemmed	Platelet-rich fibrin: Basics of biological actions and protocol modifications
title_sort	platelet-rich fibrin: basics of biological actions and protocol modifications
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/f73a414ac17947968aa511c75ef726e8
work_keys_str_mv	AT pavlovicvoja plateletrichfibrinbasicsofbiologicalactionsandprotocolmodifications AT ciricmilan plateletrichfibrinbasicsofbiologicalactionsandprotocolmodifications AT jovanovicvladimir plateletrichfibrinbasicsofbiologicalactionsandprotocolmodifications AT trandafilovicmilena plateletrichfibrinbasicsofbiologicalactionsandprotocolmodifications AT stojanovicpredrag plateletrichfibrinbasicsofbiologicalactionsandprotocolmodifications
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Platelet-rich fibrin: Basics of biological actions and protocol modifications

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