Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.

<h4>Objective</h4>The association between type 2 diabetes and low testosterone has been well recognized. However, testosterone levels in men with prediabetes have been rarely reported. We aimed to investigate whether prediabetes was associated with an increased risk of testosterone defic...

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Autores principales:	Chen-Hsun Ho, Hong-Jeng Yu, Chih-Yuan Wang, Fu-Shan Jaw, Ju-Ton Hsieh, Wan-Chung Liao, Yeong-Shiau Pu, Shih-Ping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f73b46daec6c433fb6f09c03a07d7588
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spelling	oai:doaj.org-article:f73b46daec6c433fb6f09c03a07d75882021-11-18T08:55:30ZPrediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.1932-620310.1371/journal.pone.0074173https://doaj.org/article/f73b46daec6c433fb6f09c03a07d75882013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24069277/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The association between type 2 diabetes and low testosterone has been well recognized. However, testosterone levels in men with prediabetes have been rarely reported. We aimed to investigate whether prediabetes was associated with an increased risk of testosterone deficiency.<h4>Methods</h4>This study included 1,306 men whose sex hormones was measured during a medical examination. Serum total testosterone and sex hormone-binding globulin were measured; free and bioavailable testosterone concentrations were calculated by Vermeulen's formula. Prediabetes was defined by impaired fasting glucose (IFG), impaired postprandial glucose (IPG), or glycated hemoglobin (HbA1c) 5.7%-6.4%. Logistic regression was performed to obtain the odds ratios (OR) for subnormal total testosterone (<300 ng/dL) or free testosterone (<6 ng/dL) in prediabetic and diabetic men compared with normoglycemic individuals, while adjusting for age, BMI, waist circumference, and metabolic syndrome (MetS).<h4>Results</h4>Normoglycemia, prediabetes, and diabetes were diagnosed in 577 (44.2%), 543 (41.6%), and 186 (14.2%) men, respectively. Prediabetes was associated with an increased risk of subnormal total testosterone compared to normoglycemic individuals (age-adjusted OR=1.87; 95%CI=1.38-2.54). The risk remained significant in all multivariate analyses. After adjusting for MetS, the OR in prediabetic men equals that of diabetic patients (1.49 versus 1.50). IFG, IPG, and HbA1c 5.7%-6.4% were all associated with an increased risk of testosterone deficiency, with different levels of significance in multivariate analyses. However, neither prediabetes nor diabetes was associated with subnormal free testosterone in multivariate analyses.<h4>Conclusions</h4>Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and MetS. After adjusting for MetS, the risk equals that of diabetes. Our data suggest that testosterone should be measured routinely in men with prediabetes.Chen-Hsun HoHong-Jeng YuChih-Yuan WangFu-Shan JawJu-Ton HsiehWan-Chung LiaoYeong-Shiau PuShih-Ping LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74173 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen-Hsun Ho Hong-Jeng Yu Chih-Yuan Wang Fu-Shan Jaw Ju-Ton Hsieh Wan-Chung Liao Yeong-Shiau Pu Shih-Ping Liu Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
description	<h4>Objective</h4>The association between type 2 diabetes and low testosterone has been well recognized. However, testosterone levels in men with prediabetes have been rarely reported. We aimed to investigate whether prediabetes was associated with an increased risk of testosterone deficiency.<h4>Methods</h4>This study included 1,306 men whose sex hormones was measured during a medical examination. Serum total testosterone and sex hormone-binding globulin were measured; free and bioavailable testosterone concentrations were calculated by Vermeulen's formula. Prediabetes was defined by impaired fasting glucose (IFG), impaired postprandial glucose (IPG), or glycated hemoglobin (HbA1c) 5.7%-6.4%. Logistic regression was performed to obtain the odds ratios (OR) for subnormal total testosterone (<300 ng/dL) or free testosterone (<6 ng/dL) in prediabetic and diabetic men compared with normoglycemic individuals, while adjusting for age, BMI, waist circumference, and metabolic syndrome (MetS).<h4>Results</h4>Normoglycemia, prediabetes, and diabetes were diagnosed in 577 (44.2%), 543 (41.6%), and 186 (14.2%) men, respectively. Prediabetes was associated with an increased risk of subnormal total testosterone compared to normoglycemic individuals (age-adjusted OR=1.87; 95%CI=1.38-2.54). The risk remained significant in all multivariate analyses. After adjusting for MetS, the OR in prediabetic men equals that of diabetic patients (1.49 versus 1.50). IFG, IPG, and HbA1c 5.7%-6.4% were all associated with an increased risk of testosterone deficiency, with different levels of significance in multivariate analyses. However, neither prediabetes nor diabetes was associated with subnormal free testosterone in multivariate analyses.<h4>Conclusions</h4>Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and MetS. After adjusting for MetS, the risk equals that of diabetes. Our data suggest that testosterone should be measured routinely in men with prediabetes.
format	article
author	Chen-Hsun Ho Hong-Jeng Yu Chih-Yuan Wang Fu-Shan Jaw Ju-Ton Hsieh Wan-Chung Liao Yeong-Shiau Pu Shih-Ping Liu
author_facet	Chen-Hsun Ho Hong-Jeng Yu Chih-Yuan Wang Fu-Shan Jaw Ju-Ton Hsieh Wan-Chung Liao Yeong-Shiau Pu Shih-Ping Liu
author_sort	Chen-Hsun Ho
title	Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
title_short	Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
title_full	Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
title_fullStr	Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
title_full_unstemmed	Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
title_sort	prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f73b46daec6c433fb6f09c03a07d7588
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Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.

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