Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin

Meng-Zhu Yao,1 Ming-Yi Huang-Fu,1 Hui-Na Liu,1 Xia-Rong Wang,1 Xiaoxia Sheng,2 Jian-Qing Gao1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 2Hangzhou SoliPharma Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China Abstract: Nano-hydroxyapatite/...

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Autores principales:	Yao MZ, Huang-Fu MY, Liu HN, Wang XR, Sheng XX, Gao JQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	tissue engineering nano-hydroxyapatite polyamide 66 porous scaffold carbon nanotubes silk fibroin surface modification dexamethasone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f73bc4e056e14ee3a49c179889f970a7
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spelling	oai:doaj.org-article:f73bc4e056e14ee3a49c179889f970a72021-12-02T02:06:52ZFabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin1178-2013https://doaj.org/article/f73bc4e056e14ee3a49c179889f970a72016-11-01T00:00:00Zhttps://www.dovepress.com/fabrication-and-characterization-of-drug-loaded-nano-hydroxyapatitepol-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Meng-Zhu Yao,1 Ming-Yi Huang-Fu,1 Hui-Na Liu,1 Xia-Rong Wang,1 Xiaoxia Sheng,2 Jian-Qing Gao1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 2Hangzhou SoliPharma Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China Abstract: Nano-hydroxyapatite/polyamide 66 (nHA/PA66) porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs) and silk fibroin (SF) were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected. In addition, the morphology and mechanical property of the scaffolds were investigated. The results showed that the nHA/PA66 scaffolds modified with CNTs and SF met the requirements of bone tissue engineering scaffolds. The dexamethasone-loaded CNT/SF-nHA/PA66 composite scaffold promoted the osteogenic differentiation of BMSCs, and the drug-loaded scaffolds are expected to function as effective bone tissue engineering scaffolds. Keywords: BMSCs, tissue engineering, porous scaffold, carbon nanotubes, silk fibroin, surface modification, dexamethasoneYao MZHuang-Fu MYLiu HNWang XRSheng XXGao JQDove Medical Pressarticletissue engineeringnano-hydroxyapatitepolyamide 66porous scaffoldcarbon nanotubessilk fibroinsurface modificationdexamethasoneMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 6181-6194 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue engineering nano-hydroxyapatite polyamide 66 porous scaffold carbon nanotubes silk fibroin surface modification dexamethasone Medicine (General) R5-920
spellingShingle	tissue engineering nano-hydroxyapatite polyamide 66 porous scaffold carbon nanotubes silk fibroin surface modification dexamethasone Medicine (General) R5-920 Yao MZ Huang-Fu MY Liu HN Wang XR Sheng XX Gao JQ Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
description	Meng-Zhu Yao,1 Ming-Yi Huang-Fu,1 Hui-Na Liu,1 Xia-Rong Wang,1 Xiaoxia Sheng,2 Jian-Qing Gao1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 2Hangzhou SoliPharma Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China Abstract: Nano-hydroxyapatite/polyamide 66 (nHA/PA66) porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs) and silk fibroin (SF) were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected. In addition, the morphology and mechanical property of the scaffolds were investigated. The results showed that the nHA/PA66 scaffolds modified with CNTs and SF met the requirements of bone tissue engineering scaffolds. The dexamethasone-loaded CNT/SF-nHA/PA66 composite scaffold promoted the osteogenic differentiation of BMSCs, and the drug-loaded scaffolds are expected to function as effective bone tissue engineering scaffolds. Keywords: BMSCs, tissue engineering, porous scaffold, carbon nanotubes, silk fibroin, surface modification, dexamethasone
format	article
author	Yao MZ Huang-Fu MY Liu HN Wang XR Sheng XX Gao JQ
author_facet	Yao MZ Huang-Fu MY Liu HN Wang XR Sheng XX Gao JQ
author_sort	Yao MZ
title	Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
title_short	Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
title_full	Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
title_fullStr	Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
title_full_unstemmed	Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
title_sort	fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f73bc4e056e14ee3a49c179889f970a7
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Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin

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