The SARS-CoV-2 spike protein is vulnerable to moderate electric fields

The SARS-CoV-2 spike protein is vulnerable to moderate electric fields

The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate static electric fields, and undergoes field-in...

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Autores principales: Claudia R. Arbeitman, Pablo Rojas, Pedro Ojeda-May, Martin E. Garcia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f73e86f1ec1b4d70b4028c0b1c703247
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spelling oai:doaj.org-article:f73e86f1ec1b4d70b4028c0b1c7032472021-12-02T18:02:07ZThe SARS-CoV-2 spike protein is vulnerable to moderate electric fields10.1038/s41467-021-25478-72041-1723https://doaj.org/article/f73e86f1ec1b4d70b4028c0b1c7032472021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25478-7https://doaj.org/toc/2041-1723The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate static electric fields, and undergoes field-induced conformational changes that hinder binding to ACE2.Claudia R. ArbeitmanPablo RojasPedro Ojeda-MayMartin E. GarciaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Claudia R. Arbeitman
Pablo Rojas
Pedro Ojeda-May
Martin E. Garcia
The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
description The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate static electric fields, and undergoes field-induced conformational changes that hinder binding to ACE2.
format article
author Claudia R. Arbeitman
Pablo Rojas
Pedro Ojeda-May
Martin E. Garcia
author_facet Claudia R. Arbeitman
Pablo Rojas
Pedro Ojeda-May
Martin E. Garcia
author_sort Claudia R. Arbeitman
title The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
title_short The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
title_full The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
title_fullStr The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
title_full_unstemmed The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
title_sort sars-cov-2 spike protein is vulnerable to moderate electric fields
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f73e86f1ec1b4d70b4028c0b1c703247
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