Efficacy Of Lyophilized Inactivated Rabies Vaccine

An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms. Inactivated rabies vaccine prepared from BHK21 infected cell culture in the two forms revealed that its immunogenicity was completely preserv...

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Autores principales:	Omaima A. A. Alshamandy, Heba M. G. Abd El-Aziz
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	immunoglobulins lyophilization rabies vaccine Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.120348 https://doaj.org/article/f7434f5633f44ae0a5aa7eeab68c331e
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spelling	oai:doaj.org-article:f7434f5633f44ae0a5aa7eeab68c331e2021-12-02T16:34:21ZEfficacy Of Lyophilized Inactivated Rabies Vaccinehttps://dx.doi.org/10.21608/javs.2020.1203481687-40722090-3308https://doaj.org/article/f7434f5633f44ae0a5aa7eeab68c331e2020-10-01T00:00:00Zhttps://javs.journals.ekb.eg/article_120348.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms. Inactivated rabies vaccine prepared from BHK21 infected cell culture in the two forms revealed that its immunogenicity was completely preserved on lyophilization. The two vaccine formulae were found to be free from foreign contaminants, safe in both inoculated mice and puppies and potent inducing high levels of specific rabies antibodies in vaccinated puppies. Such antibodies were increased gradually from the first-week post-vaccination to the same extent in the blood of immunized puppies with the lyophilized vaccine as in that of puppies immunized with liquid vaccine. These results confirmed the claim that inactivated rabies vaccines could be lyophilized with retention of potency. Considering the possible value of a stable, freeze-dried rabies vaccine that could be stored and transported with ease, it was considered desirable to confirm the above findings.Omaima A. A. AlshamandyHeba M. G. Abd El-AzizEgyptian Society for Animal ManagementarticleimmunoglobulinslyophilizationrabiesvaccineZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 4, Pp 68-72 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunoglobulins lyophilization rabies vaccine Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	immunoglobulins lyophilization rabies vaccine Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Omaima A. A. Alshamandy Heba M. G. Abd El-Aziz Efficacy Of Lyophilized Inactivated Rabies Vaccine
description	An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms. Inactivated rabies vaccine prepared from BHK21 infected cell culture in the two forms revealed that its immunogenicity was completely preserved on lyophilization. The two vaccine formulae were found to be free from foreign contaminants, safe in both inoculated mice and puppies and potent inducing high levels of specific rabies antibodies in vaccinated puppies. Such antibodies were increased gradually from the first-week post-vaccination to the same extent in the blood of immunized puppies with the lyophilized vaccine as in that of puppies immunized with liquid vaccine. These results confirmed the claim that inactivated rabies vaccines could be lyophilized with retention of potency. Considering the possible value of a stable, freeze-dried rabies vaccine that could be stored and transported with ease, it was considered desirable to confirm the above findings.
format	article
author	Omaima A. A. Alshamandy Heba M. G. Abd El-Aziz
author_facet	Omaima A. A. Alshamandy Heba M. G. Abd El-Aziz
author_sort	Omaima A. A. Alshamandy
title	Efficacy Of Lyophilized Inactivated Rabies Vaccine
title_short	Efficacy Of Lyophilized Inactivated Rabies Vaccine
title_full	Efficacy Of Lyophilized Inactivated Rabies Vaccine
title_fullStr	Efficacy Of Lyophilized Inactivated Rabies Vaccine
title_full_unstemmed	Efficacy Of Lyophilized Inactivated Rabies Vaccine
title_sort	efficacy of lyophilized inactivated rabies vaccine
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.120348 https://doaj.org/article/f7434f5633f44ae0a5aa7eeab68c331e
work_keys_str_mv	AT omaimaaaalshamandy efficacyoflyophilizedinactivatedrabiesvaccine AT hebamgabdelaziz efficacyoflyophilizedinactivatedrabiesvaccine
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Efficacy Of Lyophilized Inactivated Rabies Vaccine

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