Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.

Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In A...

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Autores principales:	Louiza S Velentzis, Sam Egger, Emily Banks, Karen Canfell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f748bf03418b45a79c62a535812346a9
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spelling	oai:doaj.org-article:f748bf03418b45a79c62a535812346a92021-12-02T20:18:25ZMenopausal hormone therapy: Characterising users in an Australian national cross-sectional study.1932-620310.1371/journal.pone.0253725https://doaj.org/article/f748bf03418b45a79c62a535812346a92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253725https://doaj.org/toc/1932-6203Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In Australia, while overall MHT use fell when risk-related findings were published in 2002, a significant number of women continue using MHT long-term. We aimed to examine socio-demographic, health-related and lifestyle characteristics in relation to post-2002 MHT use, and to compare use for <5 and ≥5 years. Data from 1,561 participants from an Australian, national, cross-sectional survey of women aged 50-69 in 2013 were analysed. Odds ratios (ORs) were calculated using logistic regression for characteristics related to overall MHT use post-2002 and multinomial logistic regression for associations between MHT duration of use [never/<5 years/≥5 years] and personal characteristics, adjusting for sociodemographic, reproductive, health and lifestyle factors. Post-2002 MHT use was associated with increasing age (p-trend<0.001), hysterectomy versus no hysterectomy (OR:2.55, 95%CI = 1.85-3.51), bilateral oophorectomy vs no oophorectomy (OR:1.66, 95%CI = 1.09-2.53), and ever- versus never-use of therapies other than MHT for menopausal symptoms (OR:1.93, 95%CI = 1.48-2.57). Women with prior breast cancer (OR:0.35, 95%CI = 0.17-0.74) and with more children (p-trend = 0.034) were less likely than other women to use MHT. Prior hysterectomy was more strongly associated with MHT use for ≥5 years than for <5 years (p = 0.004). Ever-use of non-MHT menopausal therapies was associated with MHT use for <5 years but not with longer-term use (p = 0.004). This study reinforces the need for MHT users and their clinicians to re-evaluate continued MHT use on an ongoing basis.Louiza S VelentzisSam EggerEmily BanksKaren CanfellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0253725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Louiza S Velentzis Sam Egger Emily Banks Karen Canfell Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
description	Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In Australia, while overall MHT use fell when risk-related findings were published in 2002, a significant number of women continue using MHT long-term. We aimed to examine socio-demographic, health-related and lifestyle characteristics in relation to post-2002 MHT use, and to compare use for <5 and ≥5 years. Data from 1,561 participants from an Australian, national, cross-sectional survey of women aged 50-69 in 2013 were analysed. Odds ratios (ORs) were calculated using logistic regression for characteristics related to overall MHT use post-2002 and multinomial logistic regression for associations between MHT duration of use [never/<5 years/≥5 years] and personal characteristics, adjusting for sociodemographic, reproductive, health and lifestyle factors. Post-2002 MHT use was associated with increasing age (p-trend<0.001), hysterectomy versus no hysterectomy (OR:2.55, 95%CI = 1.85-3.51), bilateral oophorectomy vs no oophorectomy (OR:1.66, 95%CI = 1.09-2.53), and ever- versus never-use of therapies other than MHT for menopausal symptoms (OR:1.93, 95%CI = 1.48-2.57). Women with prior breast cancer (OR:0.35, 95%CI = 0.17-0.74) and with more children (p-trend = 0.034) were less likely than other women to use MHT. Prior hysterectomy was more strongly associated with MHT use for ≥5 years than for <5 years (p = 0.004). Ever-use of non-MHT menopausal therapies was associated with MHT use for <5 years but not with longer-term use (p = 0.004). This study reinforces the need for MHT users and their clinicians to re-evaluate continued MHT use on an ongoing basis.
format	article
author	Louiza S Velentzis Sam Egger Emily Banks Karen Canfell
author_facet	Louiza S Velentzis Sam Egger Emily Banks Karen Canfell
author_sort	Louiza S Velentzis
title	Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
title_short	Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
title_full	Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
title_fullStr	Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
title_full_unstemmed	Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.
title_sort	menopausal hormone therapy: characterising users in an australian national cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f748bf03418b45a79c62a535812346a9
work_keys_str_mv	AT louizasvelentzis menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy AT samegger menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy AT emilybanks menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy AT karencanfell menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy
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Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study.

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