The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.

PB1-F2 is a 90 amino acid protein that is expressed from the +1 open reading frame in the PB1 gene of some influenza A viruses and has been shown to contribute to viral pathogenicity. Notably, a serine at position 66 (66S) in PB1-F2 is known to increase virulence compared to an isogenic virus with a...

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Autores principales: Zsuzsanna T Varga, Irene Ramos, Rong Hai, Mirco Schmolke, Adolfo García-Sastre, Ana Fernandez-Sesma, Peter Palese
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/f74b89840115468bb41bf23f6754bda1
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