Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Abstract Accumulating evidence indicates that gut microbiota may regulate sex-hormone levels in the host, with effects on reproductive health. Very little is known about the development of intestinal microbiota during puberty in humans. To assess the connection between pubertal timing and fecal micr...

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Autores principales:	Katri Korpela, Sampo Kallio, Anne Salonen, Matti Hero, Anna Kaarina Kukkonen, Päivi J. Miettinen, Erkki Savilahti, Ella Kohva, Laura Kariola, Maria Suutela, Annika Tarkkanen, Willem M. de Vos, Taneli Raivio, Mikael Kuitunen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f74c3f7d26c64fde912232857c968be9
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spelling	oai:doaj.org-article:f74c3f7d26c64fde912232857c968be92021-12-05T12:15:43ZGut microbiota develop towards an adult profile in a sex-specific manner during puberty10.1038/s41598-021-02375-z2045-2322https://doaj.org/article/f74c3f7d26c64fde912232857c968be92021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02375-zhttps://doaj.org/toc/2045-2322Abstract Accumulating evidence indicates that gut microbiota may regulate sex-hormone levels in the host, with effects on reproductive health. Very little is known about the development of intestinal microbiota during puberty in humans. To assess the connection between pubertal timing and fecal microbiota, and to assess how fecal microbiota develop during puberty in comparison with adult microbiota, we utilized a Finnish allergy-prevention-trial cohort (Flora). Data collected at 13-year follow-up were compared with adult data from a different Finnish cohort. Among the 13-year-old participants we collected questionnaire information, growth data from school-health-system records and fecal samples from 148 participants. Reference adult fecal samples were received from the Health and Early Life Microbiota (HELMi) cohort (n = 840). Fecal microbiota were analyzed using 16S rRNA gene amplicon sequencing; the data were correlated with pubertal timing and compared with data on adult microbiota. Probiotic intervention in the allergy-prevention-trial cohort was considered as a confounding factor only. The main outcome was composition of the microbiota in relation to pubertal timing (time to/from peak growth velocity) in both sexes separately, and similarity to adult microbiota. In girls, fecal microbiota became more adult-like with pubertal progression (p = 0.009). No such development was observed in boys (p = 0.9). Both sexes showed a trend towards increasing relative abundance of estrogen-metabolizing Clostridia and decreasing Bacteroidia with pubertal development, but this was statistically significant in girls only (p = 0.03). In girls, pubertal timing was associated positively with exposure to cephalosporins prior to the age of 10. Our data support the hypothesis that gut microbiota, particularly members of Ruminococcaceae, may affect pubertal timing, possibly via regulating host sex-hormone levels. Trial registration The registration number for the allergy-prevention-trial cohort: ClinicalTrials.gov, NCT00298337, registered 1 March 2006—Retrospectively registered, https://clinicaltrials.gov/show/NCT00298337 . The adult-comparison cohort (HELMi) is NCT03996304.Katri KorpelaSampo KallioAnne SalonenMatti HeroAnna Kaarina KukkonenPäivi J. MiettinenErkki SavilahtiElla KohvaLaura KariolaMaria SuutelaAnnika TarkkanenWillem M. de VosTaneli RaivioMikael KuitunenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katri Korpela Sampo Kallio Anne Salonen Matti Hero Anna Kaarina Kukkonen Päivi J. Miettinen Erkki Savilahti Ella Kohva Laura Kariola Maria Suutela Annika Tarkkanen Willem M. de Vos Taneli Raivio Mikael Kuitunen Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
description	Abstract Accumulating evidence indicates that gut microbiota may regulate sex-hormone levels in the host, with effects on reproductive health. Very little is known about the development of intestinal microbiota during puberty in humans. To assess the connection between pubertal timing and fecal microbiota, and to assess how fecal microbiota develop during puberty in comparison with adult microbiota, we utilized a Finnish allergy-prevention-trial cohort (Flora). Data collected at 13-year follow-up were compared with adult data from a different Finnish cohort. Among the 13-year-old participants we collected questionnaire information, growth data from school-health-system records and fecal samples from 148 participants. Reference adult fecal samples were received from the Health and Early Life Microbiota (HELMi) cohort (n = 840). Fecal microbiota were analyzed using 16S rRNA gene amplicon sequencing; the data were correlated with pubertal timing and compared with data on adult microbiota. Probiotic intervention in the allergy-prevention-trial cohort was considered as a confounding factor only. The main outcome was composition of the microbiota in relation to pubertal timing (time to/from peak growth velocity) in both sexes separately, and similarity to adult microbiota. In girls, fecal microbiota became more adult-like with pubertal progression (p = 0.009). No such development was observed in boys (p = 0.9). Both sexes showed a trend towards increasing relative abundance of estrogen-metabolizing Clostridia and decreasing Bacteroidia with pubertal development, but this was statistically significant in girls only (p = 0.03). In girls, pubertal timing was associated positively with exposure to cephalosporins prior to the age of 10. Our data support the hypothesis that gut microbiota, particularly members of Ruminococcaceae, may affect pubertal timing, possibly via regulating host sex-hormone levels. Trial registration The registration number for the allergy-prevention-trial cohort: ClinicalTrials.gov, NCT00298337, registered 1 March 2006—Retrospectively registered, https://clinicaltrials.gov/show/NCT00298337 . The adult-comparison cohort (HELMi) is NCT03996304.
format	article
author	Katri Korpela Sampo Kallio Anne Salonen Matti Hero Anna Kaarina Kukkonen Päivi J. Miettinen Erkki Savilahti Ella Kohva Laura Kariola Maria Suutela Annika Tarkkanen Willem M. de Vos Taneli Raivio Mikael Kuitunen
author_facet	Katri Korpela Sampo Kallio Anne Salonen Matti Hero Anna Kaarina Kukkonen Päivi J. Miettinen Erkki Savilahti Ella Kohva Laura Kariola Maria Suutela Annika Tarkkanen Willem M. de Vos Taneli Raivio Mikael Kuitunen
author_sort	Katri Korpela
title	Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
title_short	Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
title_full	Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
title_fullStr	Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
title_full_unstemmed	Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
title_sort	gut microbiota develop towards an adult profile in a sex-specific manner during puberty
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f74c3f7d26c64fde912232857c968be9
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Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

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