Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria

Abstract The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for...

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Autores principales:	Anita Milicic, Christine S. Rollier, Choon Kit Tang, Rhea Longley, Adrian V. S. Hill, Arturo Reyes-Sandoval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f74c5ffaca3348a884a9626d718f804a
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spelling	oai:doaj.org-article:f74c5ffaca3348a884a9626d718f804a2021-12-02T12:32:21ZAdjuvanting a viral vectored vaccine against pre-erythrocytic malaria10.1038/s41598-017-07246-02045-2322https://doaj.org/article/f74c5ffaca3348a884a9626d718f804a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07246-0https://doaj.org/toc/2045-2322Abstract The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco®-100 and CoVaccineHTTM, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHTTM adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8+ cells, and both adjuvants resulted in increased proportion of CD8+ T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation.Anita MilicicChristine S. RollierChoon Kit TangRhea LongleyAdrian V. S. HillArturo Reyes-SandovalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anita Milicic Christine S. Rollier Choon Kit Tang Rhea Longley Adrian V. S. Hill Arturo Reyes-Sandoval Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
description	Abstract The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco®-100 and CoVaccineHTTM, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHTTM adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8+ cells, and both adjuvants resulted in increased proportion of CD8+ T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation.
format	article
author	Anita Milicic Christine S. Rollier Choon Kit Tang Rhea Longley Adrian V. S. Hill Arturo Reyes-Sandoval
author_facet	Anita Milicic Christine S. Rollier Choon Kit Tang Rhea Longley Adrian V. S. Hill Arturo Reyes-Sandoval
author_sort	Anita Milicic
title	Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
title_short	Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
title_full	Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
title_fullStr	Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
title_full_unstemmed	Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
title_sort	adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f74c5ffaca3348a884a9626d718f804a
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Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria

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