OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS

The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statisti...

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Autores principales:	S. I. Kolesnikov, A. V. Mashanov, B. Ya. Vlasov, G. G. Yushkov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	2,8,9-тригидроцинкатран 2,8,9-trihydrozincatrane acute ethanol poisoning alcohol dehydrogenase Science Q
Acceso en línea:	https://doaj.org/article/f74f2833d9e84be9a50e8957155496f2
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spelling	oai:doaj.org-article:f74f2833d9e84be9a50e8957155496f22021-11-23T06:14:17ZOXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS2541-94202587-9596https://doaj.org/article/f74f2833d9e84be9a50e8957155496f22012-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/762https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.S. I. KolesnikovA. V. MashanovB. Ya. VlasovG. G. YushkovScientific Сentre for Family Health and Human Reproduction Problemsarticle2,8,9-тригидроцинкатран2,8,9-trihydrozincatraneacute ethanol poisoningalcohol dehydrogenaseScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 115-119 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	2,8,9-тригидроцинкатран 2,8,9-trihydrozincatrane acute ethanol poisoning alcohol dehydrogenase Science Q
spellingShingle	2,8,9-тригидроцинкатран 2,8,9-trihydrozincatrane acute ethanol poisoning alcohol dehydrogenase Science Q S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
description	The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.
format	article
author	S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov
author_facet	S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov
author_sort	S. I. Kolesnikov
title	OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
title_short	OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
title_full	OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
title_fullStr	OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
title_full_unstemmed	OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
title_sort	oxidative stress as a pathogenetic link of acute ethanol poisoning and its correction with chelate zinc compounds
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/f74f2833d9e84be9a50e8957155496f2
work_keys_str_mv	AT sikolesnikov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT avmashanov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT byavlasov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT ggyushkov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds
_version_	1718417355990630400

OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS

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