Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise the interplay between the catalysis of proline isomer...

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Autores principales:	Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba
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spelling	oai:doaj.org-article:f754601d5f914b7aaa2c4a5fef0fc9ba2021-12-02T16:49:45ZCatalysis of proline isomerization and molecular chaperone activity in a tug-of-war10.1038/s41467-020-19844-02041-1723https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19844-0https://doaj.org/toc/2041-1723Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise the interplay between the catalysis of proline isomerization and molecular chaperone activity of CypA and find that both activities have opposing effects on aSyn and further show that the that cis/trans isomerization outpowers the holding activity of CypA.Filippo FavrettoDavid FloresJeremy D. BakerTimo StrohäkerLoren B. AndreasLaura J. BlairStefan BeckerMarkus ZweckstetterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Filippo Favretto David Flores Jeremy D. Baker Timo Strohäker Loren B. Andreas Laura J. Blair Stefan Becker Markus Zweckstetter Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
description	Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise the interplay between the catalysis of proline isomerization and molecular chaperone activity of CypA and find that both activities have opposing effects on aSyn and further show that the that cis/trans isomerization outpowers the holding activity of CypA.
format	article
author	Filippo Favretto David Flores Jeremy D. Baker Timo Strohäker Loren B. Andreas Laura J. Blair Stefan Becker Markus Zweckstetter
author_facet	Filippo Favretto David Flores Jeremy D. Baker Timo Strohäker Loren B. Andreas Laura J. Blair Stefan Becker Markus Zweckstetter
author_sort	Filippo Favretto
title	Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
title_short	Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
title_full	Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
title_fullStr	Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
title_full_unstemmed	Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
title_sort	catalysis of proline isomerization and molecular chaperone activity in a tug-of-war
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba
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Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

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