Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?

Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it continues to have important metabolic functions...

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Autores principales:	Elizabeth C Hersch, George R Merriam
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Growth hormone replacement deficiency adults safety efficacy Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f754d3b2f71a4d4dbc1151d71ace232f
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spelling	oai:doaj.org-article:f754d3b2f71a4d4dbc1151d71ace232f2021-12-02T06:56:10ZGrowth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?1178-1998https://doaj.org/article/f754d3b2f71a4d4dbc1151d71ace232f2008-03-01T00:00:00Zhttps://www.dovepress.com/growth-hormone-gh-releasing-hormone-and-gh-secretagogues-in-normal-agi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it continues to have important metabolic functions in adult life. Adult GH deficiency (AGHD) is a distinct clinical entity, and GH replacement in AGHD can improve body composition, strength, aerobic capacity, and mood, and may reduce vascular disease risk. While there are some hormone-related side effects, the balance of benefits and risks is generally favorable, and several countries have approved GH for clinical use in AGHD. GH secretion declines progressively and markedly with aging, and many age-related changes resemble those of partial AGHD. This suggests that replacing GH, or stimulating GH with GH-releasing hormone or a GH secretagogue could confer benefits in normal aging similar to those observed in AGHD – in particular, could reduce the loss of muscle mass, strength, and exercise capacity leading to frailty, thereby prolonging the ability to live independently. However, while most GH studies have shown body composition effects similar to those in AGHD, functional changes have been much less inconsistent, and older adults are more sensitive to GH side effects. Preliminary reports of improved cognition are encouraging, but the overall balance of benefits and risks of GH supplementation in normal aging remains uncertain.Keywords: growth hormone, growth hormone-releasing hormone, growth hormone secretagogues, aging, sarcopenia, frailtyElizabeth C HerschGeorge R MerriamDove Medical PressarticleGrowth hormone replacementdeficiencyadultssafetyefficacyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 121-129 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Growth hormone replacement deficiency adults safety efficacy Geriatrics RC952-954.6
spellingShingle	Growth hormone replacement deficiency adults safety efficacy Geriatrics RC952-954.6 Elizabeth C Hersch George R Merriam Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
description	Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it continues to have important metabolic functions in adult life. Adult GH deficiency (AGHD) is a distinct clinical entity, and GH replacement in AGHD can improve body composition, strength, aerobic capacity, and mood, and may reduce vascular disease risk. While there are some hormone-related side effects, the balance of benefits and risks is generally favorable, and several countries have approved GH for clinical use in AGHD. GH secretion declines progressively and markedly with aging, and many age-related changes resemble those of partial AGHD. This suggests that replacing GH, or stimulating GH with GH-releasing hormone or a GH secretagogue could confer benefits in normal aging similar to those observed in AGHD – in particular, could reduce the loss of muscle mass, strength, and exercise capacity leading to frailty, thereby prolonging the ability to live independently. However, while most GH studies have shown body composition effects similar to those in AGHD, functional changes have been much less inconsistent, and older adults are more sensitive to GH side effects. Preliminary reports of improved cognition are encouraging, but the overall balance of benefits and risks of GH supplementation in normal aging remains uncertain.Keywords: growth hormone, growth hormone-releasing hormone, growth hormone secretagogues, aging, sarcopenia, frailty
format	article
author	Elizabeth C Hersch George R Merriam
author_facet	Elizabeth C Hersch George R Merriam
author_sort	Elizabeth C Hersch
title	Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
title_short	Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
title_full	Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
title_fullStr	Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
title_full_unstemmed	Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?
title_sort	growth hormone (gh)-releasing hormone and gh secretagogues in normal aging: fountain of youth or pool of tantalus?
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/f754d3b2f71a4d4dbc1151d71ace232f
work_keys_str_mv	AT elizabethchersch growthhormoneghreleasinghormoneandghsecretagoguesinnormalagingfountainofyouthorpooloftantalus AT georgermerriam growthhormoneghreleasinghormoneandghsecretagoguesinnormalagingfountainofyouthorpooloftantalus
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Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?

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