Air pollutants and early origins of respiratory diseases

Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants is emerging as a critical concern in human health. Pregnancy and fetal development stages are hi...

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Autores principales:	Dasom Kim, Zi Chen, Lin-Fu Zhou, Shou-Xiong Huang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f757834246ba4ca4baa325369854d635
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spelling	oai:doaj.org-article:f757834246ba4ca4baa325369854d6352021-12-02T11:52:15ZAir pollutants and early origins of respiratory diseases2095-882X10.1016/j.cdtm.2018.03.003https://doaj.org/article/f757834246ba4ca4baa325369854d6352018-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17301020https://doaj.org/toc/2095-882XAir pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants is emerging as a critical concern in human health. Pregnancy and fetal development stages are highly susceptible to environmental exposure and tend to develop a long-term impact in later life. In this review, we briefly glance at the direct impact of outdoor and indoor air pollutants on lung diseases and pregnancy disorders. We further focus on lung complications in later life with early exposure to air pollutants. Epidemiological evidence is provided to show the association of prenatal or perinatal exposure to air pollutants with various adverse birth outcomes, such as preterm birth, lower birth weight, and lung developmental defects, which further associate with respiratory diseases and reduced lung function in children and adults. Mechanistic evidence is also discussed to support that air pollutants impact various cellular and molecular targets at early life, which link to the pathogenesis and altered immune responses related to abnormal respiratory functions and lung diseases in later life. Keywords: Air pollutants, Polycyclic aromatic hydrocarbon, Particulate matter, Early disease origin, Respiratory diseasesDasom KimZi ChenLin-Fu ZhouShou-Xiong HuangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 2, Pp 75-94 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dasom Kim Zi Chen Lin-Fu Zhou Shou-Xiong Huang Air pollutants and early origins of respiratory diseases
description	Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants is emerging as a critical concern in human health. Pregnancy and fetal development stages are highly susceptible to environmental exposure and tend to develop a long-term impact in later life. In this review, we briefly glance at the direct impact of outdoor and indoor air pollutants on lung diseases and pregnancy disorders. We further focus on lung complications in later life with early exposure to air pollutants. Epidemiological evidence is provided to show the association of prenatal or perinatal exposure to air pollutants with various adverse birth outcomes, such as preterm birth, lower birth weight, and lung developmental defects, which further associate with respiratory diseases and reduced lung function in children and adults. Mechanistic evidence is also discussed to support that air pollutants impact various cellular and molecular targets at early life, which link to the pathogenesis and altered immune responses related to abnormal respiratory functions and lung diseases in later life. Keywords: Air pollutants, Polycyclic aromatic hydrocarbon, Particulate matter, Early disease origin, Respiratory diseases
format	article
author	Dasom Kim Zi Chen Lin-Fu Zhou Shou-Xiong Huang
author_facet	Dasom Kim Zi Chen Lin-Fu Zhou Shou-Xiong Huang
author_sort	Dasom Kim
title	Air pollutants and early origins of respiratory diseases
title_short	Air pollutants and early origins of respiratory diseases
title_full	Air pollutants and early origins of respiratory diseases
title_fullStr	Air pollutants and early origins of respiratory diseases
title_full_unstemmed	Air pollutants and early origins of respiratory diseases
title_sort	air pollutants and early origins of respiratory diseases
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/f757834246ba4ca4baa325369854d635
work_keys_str_mv	AT dasomkim airpollutantsandearlyoriginsofrespiratorydiseases AT zichen airpollutantsandearlyoriginsofrespiratorydiseases AT linfuzhou airpollutantsandearlyoriginsofrespiratorydiseases AT shouxionghuang airpollutantsandearlyoriginsofrespiratorydiseases
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Air pollutants and early origins of respiratory diseases

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