Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression

Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression

Abstract Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding....

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Main Authors: Gyrid Nygaard, Lars Herfindal, Kathrine S. Asrud, Ronja Bjørnstad, Reidun K. Kopperud, Eystein Oveland, Frode S. Berven, Lene Myhren, Erling A. Hoivik, Turid Helen Felli Lunde, Marit Bakke, Stein O. Døskeland, Frode Selheim
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f75be00c06b64f34bcf497f723b222ec
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https://doaj.org/article/f75be00c06b64f34bcf497f723b222ec

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