Fluorinated rhamnosides inhibit cellular fucosylation

Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation metabolic prodrug inhibitors and demonstrated inhi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber, Thomas J. Boltje
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f75d0352f311415b8d2a6f71407cf0de
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f75d0352f311415b8d2a6f71407cf0de
record_format	dspace
spelling	oai:doaj.org-article:f75d0352f311415b8d2a6f71407cf0de2021-12-05T12:23:11ZFluorinated rhamnosides inhibit cellular fucosylation10.1038/s41467-021-27355-92041-1723https://doaj.org/article/f75d0352f311415b8d2a6f71407cf0de2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27355-9https://doaj.org/toc/2041-1723Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation metabolic prodrug inhibitors and demonstrated inhibition of cellular fucosylation.Johan F. A. PijnenborgEmiel RossingJona MerxMarek J. NogaWillem H. C. TitulaerNienke EerdenRaisa VeizajPaul B. WhiteDirk J. LefeberThomas J. BoltjeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johan F. A. Pijnenborg Emiel Rossing Jona Merx Marek J. Noga Willem H. C. Titulaer Nienke Eerden Raisa Veizaj Paul B. White Dirk J. Lefeber Thomas J. Boltje Fluorinated rhamnosides inhibit cellular fucosylation
description	Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation metabolic prodrug inhibitors and demonstrated inhibition of cellular fucosylation.
format	article
author	Johan F. A. Pijnenborg Emiel Rossing Jona Merx Marek J. Noga Willem H. C. Titulaer Nienke Eerden Raisa Veizaj Paul B. White Dirk J. Lefeber Thomas J. Boltje
author_facet	Johan F. A. Pijnenborg Emiel Rossing Jona Merx Marek J. Noga Willem H. C. Titulaer Nienke Eerden Raisa Veizaj Paul B. White Dirk J. Lefeber Thomas J. Boltje
author_sort	Johan F. A. Pijnenborg
title	Fluorinated rhamnosides inhibit cellular fucosylation
title_short	Fluorinated rhamnosides inhibit cellular fucosylation
title_full	Fluorinated rhamnosides inhibit cellular fucosylation
title_fullStr	Fluorinated rhamnosides inhibit cellular fucosylation
title_full_unstemmed	Fluorinated rhamnosides inhibit cellular fucosylation
title_sort	fluorinated rhamnosides inhibit cellular fucosylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f75d0352f311415b8d2a6f71407cf0de
work_keys_str_mv	AT johanfapijnenborg fluorinatedrhamnosidesinhibitcellularfucosylation AT emielrossing fluorinatedrhamnosidesinhibitcellularfucosylation AT jonamerx fluorinatedrhamnosidesinhibitcellularfucosylation AT marekjnoga fluorinatedrhamnosidesinhibitcellularfucosylation AT willemhctitulaer fluorinatedrhamnosidesinhibitcellularfucosylation AT nienkeeerden fluorinatedrhamnosidesinhibitcellularfucosylation AT raisaveizaj fluorinatedrhamnosidesinhibitcellularfucosylation AT paulbwhite fluorinatedrhamnosidesinhibitcellularfucosylation AT dirkjlefeber fluorinatedrhamnosidesinhibitcellularfucosylation AT thomasjboltje fluorinatedrhamnosidesinhibitcellularfucosylation
_version_	1718371994538344448

Fluorinated rhamnosides inhibit cellular fucosylation

Ejemplares similares