Fluorinated rhamnosides inhibit cellular fucosylation

Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation metabolic prodrug inhibitors and demonstrated inhi...

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Autores principales: Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber, Thomas J. Boltje
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f75d0352f311415b8d2a6f71407cf0de
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