Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis

The aim of the work was to analyze the influence of process parameters of high shear granulation on the process yield and on the morphology of granules on the basis of dynamic image analysis. The amount of added granulation liquid had a significant effect on all monitored granulometric parameters an...

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Autores principales:	Oliver Macho, Ľudmila Gabrišová, Peter Peciar, Martin Juriga, Róbert Kubinec, Pavol Rajniak, Petra Svačinová, Tereza Vařilová, Zdenka Šklubalová
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dynamic image analysis high shear granulation liquid to solid ratio granules Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/f75da2a33cc9400990283b9c9c7c3d66
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spelling	oai:doaj.org-article:f75da2a33cc9400990283b9c9c7c3d662021-11-25T18:41:34ZSystematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis10.3390/pharmaceutics131118941999-4923https://doaj.org/article/f75da2a33cc9400990283b9c9c7c3d662021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1894https://doaj.org/toc/1999-4923The aim of the work was to analyze the influence of process parameters of high shear granulation on the process yield and on the morphology of granules on the basis of dynamic image analysis. The amount of added granulation liquid had a significant effect on all monitored granulometric parameters and caused significant changes in the yield of the process. In regard of the shape, the most spherical granules with the smoothest surface were formed at a liquid to solid ratio of ≈1. The smallest granules were formed at an impeller speed of 700 rpm, but the granules formed at 500 rpm showed both the most desirable shape and the highest process yield. Variation in the shape factors relied not only on the process parameters, but also on the area equivalent diameter of the individual granules in the batch. A linear relationship was found between the amount of granulation liquid and the compressibility of the granules. Using response surface methodology, models for predicting the size of granules and process yield related to the amount of added liquid and the impeller speed were generated, on the basis of which the size of granules and yield can be determined with great accuracy.Oliver MachoĽudmila GabrišováPeter PeciarMartin JurigaRóbert KubinecPavol RajniakPetra SvačinováTereza VařilováZdenka ŠklubalováMDPI AGarticledynamic image analysishigh shear granulationliquid to solid ratiogranulesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1894, p 1894 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dynamic image analysis high shear granulation liquid to solid ratio granules Pharmacy and materia medica RS1-441
spellingShingle	dynamic image analysis high shear granulation liquid to solid ratio granules Pharmacy and materia medica RS1-441 Oliver Macho Ľudmila Gabrišová Peter Peciar Martin Juriga Róbert Kubinec Pavol Rajniak Petra Svačinová Tereza Vařilová Zdenka Šklubalová Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
description	The aim of the work was to analyze the influence of process parameters of high shear granulation on the process yield and on the morphology of granules on the basis of dynamic image analysis. The amount of added granulation liquid had a significant effect on all monitored granulometric parameters and caused significant changes in the yield of the process. In regard of the shape, the most spherical granules with the smoothest surface were formed at a liquid to solid ratio of ≈1. The smallest granules were formed at an impeller speed of 700 rpm, but the granules formed at 500 rpm showed both the most desirable shape and the highest process yield. Variation in the shape factors relied not only on the process parameters, but also on the area equivalent diameter of the individual granules in the batch. A linear relationship was found between the amount of granulation liquid and the compressibility of the granules. Using response surface methodology, models for predicting the size of granules and process yield related to the amount of added liquid and the impeller speed were generated, on the basis of which the size of granules and yield can be determined with great accuracy.
format	article
author	Oliver Macho Ľudmila Gabrišová Peter Peciar Martin Juriga Róbert Kubinec Pavol Rajniak Petra Svačinová Tereza Vařilová Zdenka Šklubalová
author_facet	Oliver Macho Ľudmila Gabrišová Peter Peciar Martin Juriga Róbert Kubinec Pavol Rajniak Petra Svačinová Tereza Vařilová Zdenka Šklubalová
author_sort	Oliver Macho
title	Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
title_short	Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
title_full	Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
title_fullStr	Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
title_full_unstemmed	Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis
title_sort	systematic study of the effects of high shear granulation parameters on process yield, granule size, and shape by dynamic image analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f75da2a33cc9400990283b9c9c7c3d66
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Systematic Study of the Effects of High Shear Granulation Parameters on Process Yield, Granule Size, and Shape by Dynamic Image Analysis

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