Transmission, diagnosis, and management of hepatitis E: an update

Santiago Mirazo,1 Natalia Ramos,1 Victoria Mainardi,2 Solange Gerona,2 Juan Arbiza1 1Laboratory of Virology, Faculty of Sciences, University of the Republic, Montevideo, Uruguay; 2Hepatic Diseases Unit, Central Hospital of the Armed Forces, Montevideo, Uruguay Abstract: Hepatitis E virus (HEV) inf...

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Autores principales:	Mirazo S, Ramos N, Mainardi V, Gerona S, Arbiza J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f75de25158e74081863620651fb5a7dc
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spelling	oai:doaj.org-article:f75de25158e74081863620651fb5a7dc2021-12-02T04:02:36ZTransmission, diagnosis, and management of hepatitis E: an update1179-1535https://doaj.org/article/f75de25158e74081863620651fb5a7dc2014-06-01T00:00:00Zhttp://www.dovepress.com/transmission-diagnosis-and-management-of-hepatitis-e-an-update-a17086https://doaj.org/toc/1179-1535 Santiago Mirazo,1 Natalia Ramos,1 Victoria Mainardi,2 Solange Gerona,2 Juan Arbiza1 1Laboratory of Virology, Faculty of Sciences, University of the Republic, Montevideo, Uruguay; 2Hepatic Diseases Unit, Central Hospital of the Armed Forces, Montevideo, Uruguay Abstract: Hepatitis E virus (HEV) infection is an important public health concern in many developing countries, causing waterborne outbreaks as well as sporadic autochthonous hepatitis. HEV is mainly transmitted by the fecal–oral route in endemic areas through drinking of contaminated water. However, zoonotic transmission from animal reservoirs to humans has also been suggested. Three additional routes of HEV transmission have been proposed to occur: blood borne, human to human, and vertical transmission from mother to child. Acute HEV infection is usually diagnosed by detecting specific anti-HEV antibodies. However, the performance of the available assays in different settings is not optimal. Analysis of HEV ribonucleic acid in biologic specimens such as stools, serum, and liver biopsy by using nucleic acid amplification techniques is also employed. Nonetheless, additional consensus regarding the best technologies suitable for serosurveys and diagnosis of acute HEV infection is also needed. This review article summarizes the current status of HEV infection end epidemiology with particular emphasis in transmission, diagnosis, and clinical management. Keywords: HEV, epidemiology, clinical features, routes of infectionMirazo SRamos NMainardi VGerona SArbiza JDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2014, Iss default, Pp 45-59 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Mirazo S Ramos N Mainardi V Gerona S Arbiza J Transmission, diagnosis, and management of hepatitis E: an update
description	Santiago Mirazo,1 Natalia Ramos,1 Victoria Mainardi,2 Solange Gerona,2 Juan Arbiza1 1Laboratory of Virology, Faculty of Sciences, University of the Republic, Montevideo, Uruguay; 2Hepatic Diseases Unit, Central Hospital of the Armed Forces, Montevideo, Uruguay Abstract: Hepatitis E virus (HEV) infection is an important public health concern in many developing countries, causing waterborne outbreaks as well as sporadic autochthonous hepatitis. HEV is mainly transmitted by the fecal–oral route in endemic areas through drinking of contaminated water. However, zoonotic transmission from animal reservoirs to humans has also been suggested. Three additional routes of HEV transmission have been proposed to occur: blood borne, human to human, and vertical transmission from mother to child. Acute HEV infection is usually diagnosed by detecting specific anti-HEV antibodies. However, the performance of the available assays in different settings is not optimal. Analysis of HEV ribonucleic acid in biologic specimens such as stools, serum, and liver biopsy by using nucleic acid amplification techniques is also employed. Nonetheless, additional consensus regarding the best technologies suitable for serosurveys and diagnosis of acute HEV infection is also needed. This review article summarizes the current status of HEV infection end epidemiology with particular emphasis in transmission, diagnosis, and clinical management. Keywords: HEV, epidemiology, clinical features, routes of infection
format	article
author	Mirazo S Ramos N Mainardi V Gerona S Arbiza J
author_facet	Mirazo S Ramos N Mainardi V Gerona S Arbiza J
author_sort	Mirazo S
title	Transmission, diagnosis, and management of hepatitis E: an update
title_short	Transmission, diagnosis, and management of hepatitis E: an update
title_full	Transmission, diagnosis, and management of hepatitis E: an update
title_fullStr	Transmission, diagnosis, and management of hepatitis E: an update
title_full_unstemmed	Transmission, diagnosis, and management of hepatitis E: an update
title_sort	transmission, diagnosis, and management of hepatitis e: an update
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/f75de25158e74081863620651fb5a7dc
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Transmission, diagnosis, and management of hepatitis E: an update

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