HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.

<h4>Background</h4>Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many c...

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Autores principales:	Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f75e628340e743d1826f6aa9ef805d53
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spelling	oai:doaj.org-article:f75e628340e743d1826f6aa9ef805d532021-12-02T20:17:13ZHSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.1932-620310.1371/journal.pone.0258053https://doaj.org/article/f75e628340e743d1826f6aa9ef805d532021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258053https://doaj.org/toc/1932-6203<h4>Background</h4>Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM.<h4>Methods</h4>This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark's level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical staining and Western blot analysis for HSP105 were performed. Pigmented nevi (n = 20) served as a control. The staining intensity and percentage of stained cells were expressed as a histochemical score (HSCORE).<h4>Results</h4>HSP105 was overexpressed in melanoma compared with nevi. Differences in the HSCORE between nevi (HSCORE = 1.05(0.15,1.50)) and CMM (HSCORE = 2.68(1.80,3.60)) were remarkable (P<0.001). Exposed site lesions, recurrent and metastatic lesions, nodular melanoma and lentigo maligna melanoma were closely associated with higher HSP105 expression (P = 0.011, P = 0.001 and P = 0.001, respectively). Moreover, no significant difference was observed in Clark's level, Breslow thickness, or lesion duration (P>0.05).<h4>Conclusion</h4>HSP105 is overexpressed in CMM. Higher HSP105 expression in lesions is associated with different clinicopathological variables. HSP105 may be a potential target for the diagnosis, treatment and prognostic prediction of CMM.Ke-Jun ChenFeng-Zeng LiQian YeMeng JiaSheng FangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258053 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ke-Jun Chen Feng-Zeng Li Qian Ye Meng Jia Sheng Fang HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
description	<h4>Background</h4>Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM.<h4>Methods</h4>This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark's level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical staining and Western blot analysis for HSP105 were performed. Pigmented nevi (n = 20) served as a control. The staining intensity and percentage of stained cells were expressed as a histochemical score (HSCORE).<h4>Results</h4>HSP105 was overexpressed in melanoma compared with nevi. Differences in the HSCORE between nevi (HSCORE = 1.05(0.15,1.50)) and CMM (HSCORE = 2.68(1.80,3.60)) were remarkable (P<0.001). Exposed site lesions, recurrent and metastatic lesions, nodular melanoma and lentigo maligna melanoma were closely associated with higher HSP105 expression (P = 0.011, P = 0.001 and P = 0.001, respectively). Moreover, no significant difference was observed in Clark's level, Breslow thickness, or lesion duration (P>0.05).<h4>Conclusion</h4>HSP105 is overexpressed in CMM. Higher HSP105 expression in lesions is associated with different clinicopathological variables. HSP105 may be a potential target for the diagnosis, treatment and prognostic prediction of CMM.
format	article
author	Ke-Jun Chen Feng-Zeng Li Qian Ye Meng Jia Sheng Fang
author_facet	Ke-Jun Chen Feng-Zeng Li Qian Ye Meng Jia Sheng Fang
author_sort	Ke-Jun Chen
title	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
title_short	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
title_full	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
title_fullStr	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
title_full_unstemmed	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.
title_sort	hsp105 expression in cutaneous malignant melanoma: correlation with clinicopathological characteristics.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f75e628340e743d1826f6aa9ef805d53
work_keys_str_mv	AT kejunchen hsp105expressionincutaneousmalignantmelanomacorrelationwithclinicopathologicalcharacteristics AT fengzengli hsp105expressionincutaneousmalignantmelanomacorrelationwithclinicopathologicalcharacteristics AT qianye hsp105expressionincutaneousmalignantmelanomacorrelationwithclinicopathologicalcharacteristics AT mengjia hsp105expressionincutaneousmalignantmelanomacorrelationwithclinicopathologicalcharacteristics AT shengfang hsp105expressionincutaneousmalignantmelanomacorrelationwithclinicopathologicalcharacteristics
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HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.

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