Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

<h4>Background</h4>α/β-Hydrolase domain containing (ABHD)12 is a recently discovered serine hydrolase that acts in vivo as a lysophospholipase for lysophosphatidylserine. Dysfunctional ABHD12 has been linked to the rare neurodegenerative disorder called PHARC (polyneuropathy, hearing los...

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Main Authors: Teija Parkkari, Raisa Haavikko, Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Miia Vaara, Marko Lehtonen, Sami Alakurtti, Jari Yli-Kauhaluoma, Tapio Nevalainen, Juha R Savinainen, Jarmo T Laitinen
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f7600b4b8e944d0bb49648130289d3b2
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