Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?

<h4>Background</h4>HIV-1 CRF01_AE accounts for an important fraction of HIV infections in Asia including China, but little is known about the phylogenetic and evolutionary history of this CRF (circulating recombinant form). In the current study, we collected a large number of 1,957 CRF01...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yassir F Abubakar, Zhefeng Meng, Xiaoyan Zhang, Jianqing Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7627ca3ca0042859b989c5584c93e4f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7627ca3ca0042859b989c5584c93e4f
record_format	dspace
spelling	oai:doaj.org-article:f7627ca3ca0042859b989c5584c93e4f2021-11-18T08:44:53ZMultiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?1932-620310.1371/journal.pone.0080487https://doaj.org/article/f7627ca3ca0042859b989c5584c93e4f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24282546/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>HIV-1 CRF01_AE accounts for an important fraction of HIV infections in Asia including China, but little is known about the phylogenetic and evolutionary history of this CRF (circulating recombinant form). In the current study, we collected a large number of 1,957 CRF01_AE gag p17 sequences with known sampling year (1990-2010) from 5 global regions representing 15 countries to better understand the phylogenetic relationships and epidemic history of CRF01_AE strains in China.<h4>Methodology/principal findings</h4>CRF01_AE gag p17 sequences were retrieved from public databases to explore phylogenetic relationships and phylogeographic dynamics of CRF01_AE in Asia by using maximum-likelihood phylogenetics and Bayesian coalescent-based analyses. We found close phylogenetic relationships between sequences from Thailand, Vietnam and China. Moreover, at least 5 independent introductions and 5 independent autochthonous clades of CRF01_AE, which descended from Thailand or Vietnam were identified in China from 1991 through 2003.<h4>Conclusion/significance</h4>The current study not only defines the migration of CRF01_AE clades to/in Asia, but also demonstrates the criticalness of identifying the circulating strains in the population for the development of vaccine and microbicides.Yassir F AbubakarZhefeng MengXiaoyan ZhangJianqing XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80487 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yassir F Abubakar Zhefeng Meng Xiaoyan Zhang Jianqing Xu Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
description	<h4>Background</h4>HIV-1 CRF01_AE accounts for an important fraction of HIV infections in Asia including China, but little is known about the phylogenetic and evolutionary history of this CRF (circulating recombinant form). In the current study, we collected a large number of 1,957 CRF01_AE gag p17 sequences with known sampling year (1990-2010) from 5 global regions representing 15 countries to better understand the phylogenetic relationships and epidemic history of CRF01_AE strains in China.<h4>Methodology/principal findings</h4>CRF01_AE gag p17 sequences were retrieved from public databases to explore phylogenetic relationships and phylogeographic dynamics of CRF01_AE in Asia by using maximum-likelihood phylogenetics and Bayesian coalescent-based analyses. We found close phylogenetic relationships between sequences from Thailand, Vietnam and China. Moreover, at least 5 independent introductions and 5 independent autochthonous clades of CRF01_AE, which descended from Thailand or Vietnam were identified in China from 1991 through 2003.<h4>Conclusion/significance</h4>The current study not only defines the migration of CRF01_AE clades to/in Asia, but also demonstrates the criticalness of identifying the circulating strains in the population for the development of vaccine and microbicides.
format	article
author	Yassir F Abubakar Zhefeng Meng Xiaoyan Zhang Jianqing Xu
author_facet	Yassir F Abubakar Zhefeng Meng Xiaoyan Zhang Jianqing Xu
author_sort	Yassir F Abubakar
title	Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
title_short	Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
title_full	Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
title_fullStr	Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
title_full_unstemmed	Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?
title_sort	multiple independent introductions of hiv-1 crf01_ae identified in china: what are the implications for prevention?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f7627ca3ca0042859b989c5584c93e4f
work_keys_str_mv	AT yassirfabubakar multipleindependentintroductionsofhiv1crf01aeidentifiedinchinawhataretheimplicationsforprevention AT zhefengmeng multipleindependentintroductionsofhiv1crf01aeidentifiedinchinawhataretheimplicationsforprevention AT xiaoyanzhang multipleindependentintroductionsofhiv1crf01aeidentifiedinchinawhataretheimplicationsforprevention AT jianqingxu multipleindependentintroductionsofhiv1crf01aeidentifiedinchinawhataretheimplicationsforprevention
_version_	1718421419894767616

Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?

Ejemplares similares