Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depr...

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Autores principales:	Jessica A. Cooper, Makiah R. Nuutinen, Victoria M. Lawlor, Brittany A. M. DeVries, Elyssa M. Barrick, Shabnam Hossein, Daniel J. Cole, Chelsea V. Leonard, Emma C. Hahn, Andrew P. Teer, Grant S. Shields, George M. Slavich, Dost Ongur, J. Eric Jensen, Fei Du, Diego A. Pizzagalli, Michael T. Treadway
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f76778c6be8941f0a384537e46ed9397
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spelling	oai:doaj.org-article:f76778c6be8941f0a384537e46ed93972021-12-02T16:53:16ZReduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression10.1038/s41467-021-23284-92041-1723https://doaj.org/article/f76778c6be8941f0a384537e46ed93972021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23284-9https://doaj.org/toc/2041-1723Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depression.Jessica A. CooperMakiah R. NuutinenVictoria M. LawlorBrittany A. M. DeVriesElyssa M. BarrickShabnam HosseinDaniel J. ColeChelsea V. LeonardEmma C. HahnAndrew P. TeerGrant S. ShieldsGeorge M. SlavichDost OngurJ. Eric JensenFei DuDiego A. PizzagalliMichael T. TreadwayNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica A. Cooper Makiah R. Nuutinen Victoria M. Lawlor Brittany A. M. DeVries Elyssa M. Barrick Shabnam Hossein Daniel J. Cole Chelsea V. Leonard Emma C. Hahn Andrew P. Teer Grant S. Shields George M. Slavich Dost Ongur J. Eric Jensen Fei Du Diego A. Pizzagalli Michael T. Treadway Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
description	Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depression.
format	article
author	Jessica A. Cooper Makiah R. Nuutinen Victoria M. Lawlor Brittany A. M. DeVries Elyssa M. Barrick Shabnam Hossein Daniel J. Cole Chelsea V. Leonard Emma C. Hahn Andrew P. Teer Grant S. Shields George M. Slavich Dost Ongur J. Eric Jensen Fei Du Diego A. Pizzagalli Michael T. Treadway
author_facet	Jessica A. Cooper Makiah R. Nuutinen Victoria M. Lawlor Brittany A. M. DeVries Elyssa M. Barrick Shabnam Hossein Daniel J. Cole Chelsea V. Leonard Emma C. Hahn Andrew P. Teer Grant S. Shields George M. Slavich Dost Ongur J. Eric Jensen Fei Du Diego A. Pizzagalli Michael T. Treadway
author_sort	Jessica A. Cooper
title	Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
title_short	Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
title_full	Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
title_fullStr	Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
title_full_unstemmed	Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
title_sort	reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f76778c6be8941f0a384537e46ed9397
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Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

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