Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report

Burak Kulaksizoğlu,1,2 Hüseyin Kara,1,2 Berkan Bodur,1,2 Murat Kuloğlu1,2 1Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey; 2Akdeniz University, Alcohol and Substance Addiction Treatment and Research Center, Antalya, Turkey Abstract: Opioid misuse and depe...

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Autores principales:	Kulaksizoğlu B, Kara H, Bodur B, Kuloğlu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	intravenous buprenorphine-naloxone pregabalin drug misuse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f769f021f0b94db78836eef0a12617b6
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spelling	oai:doaj.org-article:f769f021f0b94db78836eef0a12617b62021-12-02T10:40:09ZIntravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report1178-2021https://doaj.org/article/f769f021f0b94db78836eef0a12617b62018-11-01T00:00:00Zhttps://www.dovepress.com/intravenous-buprenorphinenaloxone-and-concomitant-oral-pregabalin-misu-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Burak Kulaksizoğlu,1,2 Hüseyin Kara,1,2 Berkan Bodur,1,2 Murat Kuloğlu1,2 1Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey; 2Akdeniz University, Alcohol and Substance Addiction Treatment and Research Center, Antalya, Turkey Abstract: Opioid misuse and dependence are major medical and social concerns worldwide. Buprenorphine/naloxone combination (BNC) is a drug that has misuse potential and is used to treat opioid dependence, including buprenorphine and naloxone. Buprenorphine shows its pharmacological effects by binding to opioid receptors. Buprenorphine is a partial agonist and has smaller maximal effects compared to those of full agonists (heroin, methadone). Naloxone is a non-selective opiate antagonist added to buprenorphine for the prevention of intravenous diversion. BNC is used in the treatment of opioid dependence for detoxification and maintenance. The drug should be used as a sublingual film tablet. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorders. It is increasingly being reported as possessing a potential for misuse. In this article, we present a case of intravenous BNC and concomitant oral pregabalin misuse that developed in a monitored and treated patient for the reason of opioid dependence. Keywords: intravenous buprenorphine–naloxone, pregabalin, drug misuse, opioid addictionKulaksizoğlu BKara HBodur BKuloğlu MDove Medical Pressarticleintravenous buprenorphine-naloxonepregabalindrug misuseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3033-3035 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	intravenous buprenorphine-naloxone pregabalin drug misuse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	intravenous buprenorphine-naloxone pregabalin drug misuse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kulaksizoğlu B Kara H Bodur B Kuloğlu M Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
description	Burak Kulaksizoğlu,1,2 Hüseyin Kara,1,2 Berkan Bodur,1,2 Murat Kuloğlu1,2 1Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey; 2Akdeniz University, Alcohol and Substance Addiction Treatment and Research Center, Antalya, Turkey Abstract: Opioid misuse and dependence are major medical and social concerns worldwide. Buprenorphine/naloxone combination (BNC) is a drug that has misuse potential and is used to treat opioid dependence, including buprenorphine and naloxone. Buprenorphine shows its pharmacological effects by binding to opioid receptors. Buprenorphine is a partial agonist and has smaller maximal effects compared to those of full agonists (heroin, methadone). Naloxone is a non-selective opiate antagonist added to buprenorphine for the prevention of intravenous diversion. BNC is used in the treatment of opioid dependence for detoxification and maintenance. The drug should be used as a sublingual film tablet. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorders. It is increasingly being reported as possessing a potential for misuse. In this article, we present a case of intravenous BNC and concomitant oral pregabalin misuse that developed in a monitored and treated patient for the reason of opioid dependence. Keywords: intravenous buprenorphine–naloxone, pregabalin, drug misuse, opioid addiction
format	article
author	Kulaksizoğlu B Kara H Bodur B Kuloğlu M
author_facet	Kulaksizoğlu B Kara H Bodur B Kuloğlu M
author_sort	Kulaksizoğlu B
title	Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
title_short	Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
title_full	Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
title_fullStr	Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
title_full_unstemmed	Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
title_sort	intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f769f021f0b94db78836eef0a12617b6
work_keys_str_mv	AT kulaksizoglub intravenousbuprenorphinenaloxoneandconcomitantoralpregabalinmisuseacasereport AT karah intravenousbuprenorphinenaloxoneandconcomitantoralpregabalinmisuseacasereport AT bodurb intravenousbuprenorphinenaloxoneandconcomitantoralpregabalinmisuseacasereport AT kuloglum intravenousbuprenorphinenaloxoneandconcomitantoralpregabalinmisuseacasereport
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Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report

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