Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

The effect of histone H4 lysine 20 methylation (H4K20me) on chromatin accessibility are not well established. Here the authors show how H4K20 methylation regulates chromatin structure and accessibility to ensure precise transcriptional outputs through the cell cycle using genome-wide approaches, in...

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Autores principales: Muhammad Shoaib, Qinming Chen, Xiangyan Shi, Nidhi Nair, Chinmayi Prasanna, Renliang Yang, David Walter, Klaus S. Frederiksen, Hjorleifur Einarsson, J. Peter Svensson, Chuan Fa Liu, Karl Ekwall, Mads Lerdrup, Lars Nordenskiöld, Claus S. Sørensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f76a361292764d62aaec51000b152860
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spelling oai:doaj.org-article:f76a361292764d62aaec51000b1528602021-12-02T18:01:17ZHistone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes10.1038/s41467-021-25051-22041-1723https://doaj.org/article/f76a361292764d62aaec51000b1528602021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25051-2https://doaj.org/toc/2041-1723The effect of histone H4 lysine 20 methylation (H4K20me) on chromatin accessibility are not well established. Here the authors show how H4K20 methylation regulates chromatin structure and accessibility to ensure precise transcriptional outputs through the cell cycle using genome-wide approaches, in vitro biophysical assays, and NMR.Muhammad ShoaibQinming ChenXiangyan ShiNidhi NairChinmayi PrasannaRenliang YangDavid WalterKlaus S. FrederiksenHjorleifur EinarssonJ. Peter SvenssonChuan Fa LiuKarl EkwallMads LerdrupLars NordenskiöldClaus S. SørensenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Muhammad Shoaib
Qinming Chen
Xiangyan Shi
Nidhi Nair
Chinmayi Prasanna
Renliang Yang
David Walter
Klaus S. Frederiksen
Hjorleifur Einarsson
J. Peter Svensson
Chuan Fa Liu
Karl Ekwall
Mads Lerdrup
Lars Nordenskiöld
Claus S. Sørensen
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
description The effect of histone H4 lysine 20 methylation (H4K20me) on chromatin accessibility are not well established. Here the authors show how H4K20 methylation regulates chromatin structure and accessibility to ensure precise transcriptional outputs through the cell cycle using genome-wide approaches, in vitro biophysical assays, and NMR.
format article
author Muhammad Shoaib
Qinming Chen
Xiangyan Shi
Nidhi Nair
Chinmayi Prasanna
Renliang Yang
David Walter
Klaus S. Frederiksen
Hjorleifur Einarsson
J. Peter Svensson
Chuan Fa Liu
Karl Ekwall
Mads Lerdrup
Lars Nordenskiöld
Claus S. Sørensen
author_facet Muhammad Shoaib
Qinming Chen
Xiangyan Shi
Nidhi Nair
Chinmayi Prasanna
Renliang Yang
David Walter
Klaus S. Frederiksen
Hjorleifur Einarsson
J. Peter Svensson
Chuan Fa Liu
Karl Ekwall
Mads Lerdrup
Lars Nordenskiöld
Claus S. Sørensen
author_sort Muhammad Shoaib
title Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
title_short Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
title_full Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
title_fullStr Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
title_full_unstemmed Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
title_sort histone h4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f76a361292764d62aaec51000b152860
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